PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer (CAT#: MHC-CN1265)
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Figure 3 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
Specifications
- Allele
- A*02:01
- Class
- Class I
- Antigen
- TGFB1
- Antigen Species
- Human
- Peptide
- RLSSCVPVA
- Conjugate
- PE
- Application
- FCM, IHC
Target
- Antigen Introduction
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
- Alternative Names
- CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta
- Gene ID
- 7040
- UniProt ID
- P01137
Related Resources
Inflammatory Bowel Diseases
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-N0392-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0392-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-N0393-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0393-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-0037-WJ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0037-WJ-S(P)) | ELISA, WB | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-634CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-634CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-635CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-636CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-636CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-637CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-637CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-638CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-638CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-639CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-639CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1095MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to APC | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1096MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1097MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AMCA | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1098MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-28G11) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-20B9) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 2Ar2) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0392-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0392-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0393-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0393-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0394-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0394-YC-F(E)) | IHC, Neut, FuncS | Human Fab |
| HPAB-0308CQ-F(E) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 2471); Fab Fragment | ELISA, Neut, FC | Mouse Fab |
| HPAB-0309CQ-F(E) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 1021); Fab Fragment | ELISA, Neut, FC | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Fresolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Metelimumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2101-FY | Human Anti-TGFB1 Recombinant Antibody (clone SL15A) | Inhib, ELISA | Human IgG4, κ |
| HPAB-2102-FY | Human Anti-TGFB1 Recombinant Antibody (clone SL15S) | Inhib, ELISA | Human IgG4, κ |
| ZG-0116C | Mouse Anti-TGFB1 Recombinant Antibody (clone 10E5) | IHC-P, IF | Mouse IgG |
| ZG-0117C | Mouse Anti-TGFB1 Recombinant Antibody (clone 5D2) | IHC-P, IF | Mouse IgG |
| VS3-WK1260 | Mouse Anti-TGFB1 Recombinant Antibody (VS3-WK1260) | ELISA, WB | Mouse IgG2b |
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