Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-140)
CAT#: AFC-TAB-140
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to TGF-beta. It is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
❮
❯
Specifications
- Immunogen
- A synthetic peptide (17 aa) derived from C terminal human TGF beta 3 protein.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Fresolimumab
- Related Disease
- Idiopathic pulmonary fibrosis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AFC-TAB-140. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Fresolimumab"
DrugMonitor™ Anti-Fresolimumab Antibody (VS-1224-YC491)Fresolimumab binds to and inhibits all isoforms of TGF-beta, utilized in trials for treating primary brain tumors, metastatic breast cancer, diffuse systemic sclerosis, malignant pleural mesothelioma, and primary focal segmental glomerulosclerosis. The DrugMonitor™ Anti-Fresolimumab Antibody (VS-1224-YC491) is an anti-drug antibody (ADA) against Fresolimumab. This drug-based antibody is raised in mice immunized with the Fresolimumab. The anti-Fresolimumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Fresolimumab in samples.
See other products for "Tgfb1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-344 | Human Anti-TGFB1 Recombinant Antibody (PSBL-344); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0037-WJ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0037-WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-2101-FY-S(P) | Human Anti-TGFB1 Recombinant Antibody (clone SL15A); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-2102-FY-S(P) | Human Anti-TGFB1 Recombinant Antibody (clone SL15S); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-2107-FY-S(P) | Human Anti-TGFB1 Recombinant Antibody (clone 31G9); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-632CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-632CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-634CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-634CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT | Human Anti-TGFB1 Recombinant Antibody (TAB-635CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-636CT | Human Anti-TGFB1 Recombinant Antibody (TAB-636CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-637CT | Human Anti-TGFB1 Recombinant Antibody (TAB-637CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-638CT | Human Anti-TGFB1 Recombinant Antibody (TAB-638CT) | ELISA, WB, FC, IP | Human IgG1 |
| TAB-639CT | Human Anti-TGFB1 Recombinant Antibody (TAB-639CT) | ELISA, WB, FC, IP | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2004CQ) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2005CQ) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0392-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0392-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-N0393-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-N0393-YC-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-2101-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15A); Fab Fragment | Inhib, ELISA | Human Fab, κ |
| HPAB-2102-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15S); Fab Fragment | Inhib, ELISA | Human Fab, κ |
| HPAB-2107-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone 31G9); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0308CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 2471) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0309CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 1021) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0310CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 3821) | ELISA, Neut, FC | Mouse IgG |
| HPAB-0311CQ | Human Anti-TGFB1 Recombinant Antibody (HPAB-0311CQ) | ELISA, Neut, FuncS | Human IgG4, κ |
| HPAB-0312CQ | Human Anti-TGFB1 Recombinant Antibody (HPAB-0312CQ) | ELISA, Neut, FuncS | Human IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-762) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY252 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252) | IP, Protein Purification | |
| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY14 | Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7208 | Anti-TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7209 | Anti-Mouse TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7210 | Anti-Rat TGFB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC230 | Recombinant Anti-TGFB1 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: Neut, ELISA, FuncS
Application: ELISA, SPR, Inhib, FuncS
-2.png)
Application: IB, ELISA, FC, FuncS
Application: ELISA, FC, WB, Block
Application: FC, ADCC, CDC, Inhib
Application: ELISA, PD, Activ, PK, Stim
Application: ELISA, FC, Inhib
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
Application: ELISA, FC, WB, Inhib, IHC
Application: ELISA, FC, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
