Human Anti-TNFRSF8 Recombinant Antibody (clone 5F11) (CAT#: HPAB-1931-FY)

This product is a recombinant antibody that recognizes TNFRSF8. The monoclonal antibody 5F11 reacts with the epitope of TNFRSF8.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 Shows a graph comparing dose dependent binding of anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control to recombinant CD30.

Figure 1 Shows a graph comparing dose dependent binding of anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control to recombinant CD30.

FC

Figure 2 Shows a graph comparing dose dependent binding of anti-CD30 HuMabs, 17G 1, 5F11, 2H9 and an isotype control to the Hodgkin's lymphoma cell line, L540.

Figure 2 Shows a graph comparing dose dependent binding of anti-CD30 HuMabs, 17G 1, 5F11, 2H9 and an isotype control to the Hodgkin's lymphoma cell line, L540.

ADCC

Figure 3 Shows a graph comparing mononuclear cell-mediated antibody dependent cellular cytotoxicity of L540 Hodgkin's tumor cells by anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control.

Figure 3 Shows a graph comparing mononuclear cell-mediated antibody dependent cellular cytotoxicity of L540 Hodgkin's tumor cells by anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control.

ADCC

Figure 4 Shows a graph comparing monocyte-mediated antibody dependent cellular cytotoxicity of L540 Hodgkin's tumor cells by anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control.

Figure 4 Shows a graph comparing monocyte-mediated antibody dependent cellular cytotoxicity of L540 Hodgkin's tumor cells by anti-CD30 HuMabs, 17G1, 5F11, 2H9 and an isotype control.

Inhib

Figure 5 A graph shows the inhibition of cell growth using HuMab 5F11.

Figure 5 A graph shows the inhibition of cell growth using HuMab 5F11.

Inhib

Figure 6 A graph shows the growth inhibition of CD30-expressing tumor cells by HuMab 5F11 in vivo using a xenografted mouse model.

Figure 6 A graph shows the growth inhibition of CD30-expressing tumor cells by HuMab 5F11 in vivo using a xenografted mouse model.

FuncS

Figure 7 A graph shows the effects of HuMab 5F11 treatment on the survival of SCID mice challenged with human HL cells L540CY in a disseminated model.

Figure 7 A graph shows the effects of HuMab 5F11 treatment on the survival of SCID mice challenged with human HL cells L540CY in a disseminated model.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human TNFRSF8
  • Species Reactivity
  • Human
  • Clone
  • 5F11
  • Applications
  • ELISA, FC, ADCC, Inhib, FuncS
  • Related Disease
  • Non-Hodgkin's lymphomas (NHL), including Burkitt's lymphoma

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The TNFRSF8 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Antibody-dependent Cell-mediated Cytotoxicity, Inhibition, Functional Assay.

Target

  • Alternative Names
  • TNF Receptor Superfamily Member 8; Lymphocyte Activation Antigen CD30; CD30L Receptor; Ki-1 Antigen; D1S166E; CD30

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 5F11"

See other products for "TNFRSF8"

Human Antibody

CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-153 Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Human IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G062E Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G062R Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G062S Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-L041R anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L041S anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap Cytotoxicity assay, Functional assay

Humanized Antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-139LC Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-139LC-1 Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0597MZ Chicken Anti-TNFRSF8 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2165CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) FC, Stim, Costim, Block Hamster IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2166CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) Neut, FC Hamster IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-144 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-153 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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