Human Anti-TNFSF13B Recombinant Antibody (clone h8E7D9C7F5-1); Fab Fragment

Name: Human Anti-TNFSF13B Recombinant Antibody (clone h8E7D9C7F5-1); Fab Fragment
SKU: HPAB-N0286-YC-F(E)
Rating: 5 (1 reviews)

CAT#: HPAB-N0286-YC-F(E)

The BLyS has high affinity, and can remarkably effectively block a BLyS protein at a protein level and a cellular level to prevent the binding of the BLyS protein to a receptor. The BLyS antibody has no cross-reactivity with human APRIL and like protein antigens, has good biological activity, and can inhibit the proliferation of mouse B-cells induced by human BLyS. so the BLyS antibody can be used in the preparation of a medicine for preventing or treating diseases associated with BLyS expression or dysfunction.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line THP-1

Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg

Normal Tissue Figure 5 Colon

Peripheral nerve/ganglion
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg

Normal Tissue Figure 9 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

❮

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Specifications

Immunogen
Human protein extracellular domain of BLyS (BLyS-ECD) in Alal34-Leu285 amino acid sequence

Host Species
Human

Derivation
Phage display library

Type
Human Fab

Specificity
Human TNFSF13B

Species Reactivity
Human, Monkey

Clone
h8E7D9C7F5-1

Applications
ELISA, FC, Inhib

Related Disease
Autoimmune Diseases

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNF Superfamily Member 13b; Tumor Necrosis Factor (Ligand) Superfamily, Member 13b; Dendritic Cell-Derived TNF-Like Molecule; B-Cell-Activating Factor; TNFSF20; TALL-1; TALL1; ZTNF4; BAFF; BLYS; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; Tumor Necrosis Factor Ligand Superfamily Member 13B; TNF-And APOL-Related Leukocyte Expressed Ligand 1; TNF And ApoL-Related Leukocyte Expressed Ligand 1; Tumor Necrosis Factor Superfamily Member 13b

Gene ID
10673

UniProt ID
Q9Y275

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-N0286-YC-F(E).pdf

MSDS

MSDS - HPAB-N0286-YC-F(E).pdf

COA

Certificate of Analysis Lookup

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CAT
Product Name

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