Recombinant Anti-TNFSF13B Vesicular Antibody, EV Displayed (VS-0425-YC601) (CAT#: VS-0425-YC601)
The Recombinant Anti-TNFSF13B Vesicular Antibody, EV Displayed (VS-0425-YC601) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFSF13B-expressed cells or tissues. TNFSF13B is a TNF ligand family cytokine, acting as a potent B cell activator involved in their proliferation and differentiation.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg

Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg
(Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg

Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg

Figure 4 Cerebral cortex
(Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg
(Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg

Figure 5 Colon
(Peripheral nerve/ganglion
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg
(Peripheral nerve/ganglion
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg

Figure 6 Kidney
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg

Figure 7 Testis
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg

Figure 8 Lymph node
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg

Figure 9 Tonsil
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg
(Germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg

Figure 10 RNA cell line category: Cell line enriched (U-937)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

Figure 10 RNA cell line category: Cell line enriched (U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFSF13B
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF superfamily member 13b
- Biological Process
- Immunity
- Molecular Function
- Cytokine
- Cellular Localization
- Plasma membrane, Vesicles, Focal adhesion sites
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
- Alternative Names
- BAFF, BLYS, CD257, TALL-1, TALL1, THANK, TNFSF20
- Gene ID
- 10673
- UniProt ID
- Q9Y275
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1226z | Mouse Anti-TNFSF13B Recombinant Antibody (clone 25D8) | WB, IP, IF, ELISA | Mouse IgM, κ |
HPAB-1877LY | Human Anti-TNFSF13B Recombinant Antibody (HPAB-1877LY) | Inhib | Human IgG |
HPAB-N0286-YC | Human Anti-TNFSF13B Recombinant Antibody (clone h8E7D9C7F5-1) | ELISA, FC, Inhib | Human IgG |
FAMAB-0324JF | Mouse Anti-TNFSF13B Recombinant Antibody (clone ABL-1) | WB, ELISA, FuncS | Mouse IgG |
VS-0824-CJ2 | Mouse Anti-TNFSF13B Recombinant Antibody (clone 2-1G11) | ELISA, FC, Inhib | Mouse IgG |
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