Human Anti-TNFSF13B (clone 10B1) scFv-Fc Chimera

Name: Human Anti-TNFSF13B (clone 10B1) scFv-Fc Chimera
SKU: VS-0125-FY47
Rating: 5 (1 reviews)

CAT#: VS-0125-FY47

The anti-BAFF single-chain antibody fragment (scFv) combined with the Fc region of human IgG1 represents a novel therapeutic construct designed to specifically target and neutralize B-cell activating factor (BAFF), a key regulator in the development and survival of B cells. By leveraging the unique properties of the scFv for high specificity and the Fc region's ability to engage immune effector functions, this recombinant antibody holds promise in modulating the immune response in autoimmune disorders associated with elevated BAFF levels. Furthermore, clinical application of this innovative treatment could lead to improved management of diseases such as systemic lupus erythematosus and other BAFF-driven conditions, ultimately enhancing patient outcomes.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line THP-1

Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg

Normal Tissue Figure 5 Colon

Peripheral nerve/ganglion
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

Normal Tissue Figure 9 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

❮

❯

Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Species Reactivity
Human

Clone
10B1

Applications
ELISA, Neutralization

Related Disease
Autoimmune disease

Product Property

Purity
>95% as determined by SDS-PAGE

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Stabilizer
No Stabilizers

Sterility
0.2 μM filtered

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
This recombinant antibody could potentially be used as a therapeutic option for treating autoimmune disorders that are driven by BAFF.

Target

Alternative Names
TNF Superfamily Member 13b; Tumor Necrosis Factor (Ligand) Superfamily, Member 13b; Dendritic Cell-Derived TNF-Like Molecule; B-Cell-Activating Factor; TNFSF20; TALL-1; TALL1; ZTNF4; BAFF; BLYS; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; Tumor Necrosis Factor Ligand Superfamily Member 13B; TNF- And APOL-Related Leukocyte Expressed Ligand 1; TNF And ApoL-Related Leukocyte Expressed Ligand 1; Tumor Necrosis Factor Superfamily Member 13b

Gene ID
10673

UniProt ID
Q9Y275

Sequence Similarities
Belongs to the tumor necrosis factor (TNF) ligand family.

Cellular Localization
Secreted

Post Translation Modifications
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
N-glycosylated.
Glycosylation at Asn124 and Asn242
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites

Protein Refseq
XP_047286011.1; XP_054230009.1; NP_001139117.1; NP_006564.1

Function
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0125-FY47.pdf

MSDS

MSDS - VS-0125-FY47.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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