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    Human Anti-TNFSF13B scFv-Fc Chimera (VS-0425-FY68) (CAT#: VS-0425-FY68)

    Targeting TNFSF13B (BAFF), a cytokine critical for B-cell survival, this scFv-Fc fusion protein is designed to modulate B-cell function and has potential applications in treating autoimmune diseases and cancer by modulating the immune system.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line THP-1
    Figure 1 IF staining of human cell line THP-1
    (Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg
    Figure 2 IF staining of human cell line A549
    Figure 2 IF staining of human cell line A549
    (Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Neuronal cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Peripheral nerve/ganglion
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Leydig cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Non-germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg
    Figure 9 Tonsil
    Figure 9 Tonsil
    (Germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Non-germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Squamous epithelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enriched (U-937)
    Figure 10 RNA cell line category: Cell line enriched (U-937)
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B
    Figure 10 RNA cell line category: Cell line enriched (U-937)
    Figure 10 RNA cell line category: Cell line enriched (U-937)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

    Specifications

    • Immunogen
    • Soluble human BAFF as an immunogen.
    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human TNFSF13B
    • Species Reactivity
    • Human
    • Applications
    • ELISA
    • Related Disease
    • Autoimmune disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • TNF Superfamily Member 13b; Tumor Necrosis Factor (Ligand) Superfamily, Member 13b; Dendritic Cell-Derived TNF-Like Molecule; B-Cell-Activating Factor; TNFSF20; TALL-1; TALL1; ZTNF4; BAFF; BLYS; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; Tumor Necrosis Factor Ligand Superfamily Member 13B; TNF- And APOL-Related Leukocyte Expressed Ligand 1; TNF And ApoL-Related Leukocyte Expressed Ligand 1; Tumor Necrosis Factor Superfamily Member 13b
    • Long Name
    • TNF Superfamily Member 13b
    • Sequence Similarities
    • Belongs to the tumor necrosis factor (TNF) ligand family.
    • Cellular Localization
    • Secreted
    • Post Translation Modifications
    • The soluble form derives from the membrane form by proteolytic processing.
      Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
      N-glycosylated.
      Glycosylation at Asn124 and Asn242
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 2 sites
    • Function
    • Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "TNFSF13B"

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    CAT Product Name Application Type
    NABG-024 Recombinant Anti-Human TNFSF13B VHH Single Domain Antibody CA, IP, IF, FuncS Llama VHH
    TAB-0055CL-VHH Anti-Human TNFSF13B VHH Single Domain Antibody (TAB-0055CL-VHH) ELISA, FuncS, Inhib, BLI Single domain antibody
    HPAB-0235-YJ-VHH Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0235-YJ-VHH) ELISA, Inhib Llama VHH
    HPAB-0236-YJ-VHH Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0236-YJ-VHH) ELISA, Inhib Llama VHH
    HPAB-0237-YJ-VHH Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0237-YJ-VHH) ELISA, Inhib Llama VHH

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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