Afuco™ Anti-TNFSF13B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-030)

Name: Afuco™ Anti-TNFSF13B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-030)
SKU: AFC-TAB-030
Rating: 5 (1 reviews)

CAT#: AFC-TAB-030

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human BLyS. It is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line THP-1

Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1926_A6_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to plasma membrane, Focal adhesion sites & Vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1702_E2_13_cr5db6ea10de8f3_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to Vesicles & Focal adhesion sites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/30526/1708_E6_34_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_B_7_5.jpg

Normal Tissue Figure 5 Colon

Peripheral nerve/ganglion
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_9_3.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_6_6.jpg

Normal Tissue Figure 8 Lymph node

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_8_8.jpg

Normal Tissue Figure 9 Tonsil

Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Squamous epithelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9188/24697_A_5_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 10 RNA cell line category: Cell line enriched (U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102524-TNFSF13B

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FC, IP, ELISA, Neut, FuncS, IF

Conjugate
Unconjugated

Trade name
Benlysta

Generic Name
Belimumab

Related Disease
Systemic lupus erythematosus (SLE)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK

Gene ID
10673

UniProt ID
Q9Y275

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Biosimilar Overview

Please refer to Belimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Belimumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-030.pdf

MSDS

MSDS - AFC-TAB-030.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Belimumab"

DrugMonitor™ Anti-Belimumab Antibody (VS-1224-YC177)
Belimumab is a fully human recombinant IgG1 lambda monoclonal antibody inhibiting soluble human BLyS, first approved for systemic lupus erythematosus (SLE) and lupus nephritis treatment. The DrugMonitor™ Anti-Belimumab Antibody (VS-1224-YC177) is an anti-drug antibody (ADA) against Belimumab. This drug-based antibody is raised in mice immunized with the Belimumab. The anti-Belimumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Belimumab in samples.

See other products for "TNFSF13B"

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CAT	Product Name	Application	Type
NABG-024	Recombinant Anti-Human TNFSF13B VHH Single Domain Antibody	CA, IP, IF, FuncS	Llama VHH
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HPAB-0235-YJ-VHH	Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0235-YJ-VHH)	ELISA, Inhib	Llama VHH
HPAB-0236-YJ-VHH	Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0236-YJ-VHH)	ELISA, Inhib	Llama VHH
HPAB-0237-YJ-VHH	Recombinant Llama Anti-TNFSF13B Single Domain Antibody (HPAB-0237-YJ-VHH)	ELISA, Inhib	Llama VHH

CAT	Product Name	Application	Type
TAB-216	Anti-Human BAFF Recombinant Antibody (TAB-216)	FuncS, IF, Neut, ELISA, FC, IP, IHC	IgG4 - kappa
TAB-1162CL-S(P)	Anti-Human TNFSF13B Recombinant Antibody scFv Fragment (1B7)	ELISA, Inhib	Fully human antibody
TAB-1163CL-S(P)	Anti-Human TNFSF13B Recombinant Antibody scFv Fragment (5E12)	ELISA	Fully human antibody
TAB-1164CL-S(P)	Anti-Human TNFSF13B Recombinant Antibody scFv Fragment (5G10)	ELISA	Fully human antibody
TAB-1165CL-S(P)	Anti-Human TNFSF13B Recombinant Antibody scFv Fragment (8D12)	ELISA	Fully human antibody

CAT	Product Name	Application	Type
TAB-1157CL	Mouse Anti-TNFSF13B Recombinant Antibody (TAB-1157CL)	ELISA, WB, FuncS	Mouse IgG1
TAB-1177CL	Mouse Anti-TNFSF13B Recombinant Antibody (TAB-1177CL)	Neut	Mouse IgG
TAB-1178CL	Mouse Anti-TNFSF13B Recombinant Antibody (TAB-1178CL)	Neut	Mouse IgG
TAB-1181CL	Anti-Human TNFSF13B Recombinant Antibody (H1104-30)	ELISA, Inhib
TAB-1183CL	Mouse Anti-TNFSF13B Recombinant Antibody (TAB-1183CL)	ELISA, Inhib	Mouse IgG2b, κ

CAT	Product Name	Application	Type
TAB-1182CL	Anti-Human TNFSF13B Recombinant Antibody (H1104-30-CA)	ELISA, Inhib	Chimeric antibody (mouse/human)
TAB-1179CL-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (TAB-1179CL-S(P))	Neut	Human scFv
TAB-1179CL-F(E)	Human Anti-TNFSF13B Recombinant Antibody; Fab Fragment (TAB-1179CL-F(E))	Neut	Chimeric (Mouse/Human) Fab
TAB-1180CL-F(E)	Human Anti-TNFSF13B Recombinant Antibody; Fab Fragment (TAB-1180CL-F(E))	Neut	Chimeric (Mouse/Human) Fab
TAB-1182CL-F(E)	Anti-Human TNFSF13B Recombinant Antibody Fab Fragment (H1104-30-CA)	ELISA, Inhib	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-1194CL	Human Anti-TNFSF13B Recombinant Antibody (TAB-1194CL)	Inhib	Humanized antibody
TAB-1194CL-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (TAB-1194CL-S(P))	ELISA	Human scFv
TAB-1195CL-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (TAB-1195CL-S(P))	ELISA	Human scFv
TAB-1196CL-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (TAB-1196CL-S(P))	ELISA	Human scFv
TAB-1197CL-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (TAB-1197CL-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
NEUT-2184CQ	Rat Anti-TNFSF13B Recombinant Antibody (clone 8F10)	Neut, FC, IHC, IHC-Fr	Rat IgG2a
NEUT-2185CQ	Mouse Anti-TNFSF13B Recombinant Antibody (clone CBL701)	Neut	Mouse IgG2b

CAT	Product Name	Application	Type
MOR-3973	Rabbit Anti-TNFSF13B Recombinant Antibody (clone SI33DS)	WB, FC, IP	Rabbit IgG
MOR-4470	Rabbit Anti-TNFSF13B Recombinant Antibody (clone SI564DS)	FC	Rabbit IgG
MOR-4471	Rabbit Anti-TNFSF13B Recombinant Antibody (clone SI565DS)	ELISA	Rabbit IgG
MOR-4537	Rabbit Anti-TNFSF13B Recombinant Antibody (clone TH45DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0235-YC-S(P)	Human Anti-TNFSF13B Recombinant Antibody; scFv Fragment (HPAB-0235-YC-S(P))	ELISA, Neut	Human scFv
HPAB-1623-FY-F(E)	Mouse Anti-TNFSF13B Recombinant Antibody (clone FMMU-BAFF-4); scFv Fragment	ELISA, FC	Mouse scFv
HPAB-1255WJ-S(P)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; scFv Fragment (HPAB-1255WJ-S(P))	ELISA, WB	Human scFv
HPAB-1256WJ-S(P)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; scFv Fragment (HPAB-1256WJ-S(P))	ELISA, WB	Human scFv
HPAB-1257WJ-S(P)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; scFv Fragment (HPAB-1257WJ-S(P))	ELISA, WB	Human scFv

CAT	Product Name	Application	Type
HPAB-0121-FY-F(E)	Mouse Anti-TNFSF13B Recombinant Antibody; Fab Fragment (HPAB-0121-FY-F(E))	ELISA	Mouse Fab
HPAB-N0286-YC-F(E)	Human Anti-TNFSF13B Recombinant Antibody (clone h8E7D9C7F5-1); Fab Fragment	ELISA, FC, Inhib	Human Fab
HPAB-1255WJ-F(E)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; Fab Fragment (HPAB-1255WJ-F(E))	ELISA, WB	Human Fab
HPAB-1256WJ-F(E)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; Fab Fragment (HPAB-1256WJ-F(E))	ELISA, WB	Human Fab
HPAB-1257WJ-F(E)	Human Anti-B lymphocyte stimulator protein Recombinant Antibody; Fab Fragment (HPAB-1257WJ-F(E))	ELISA, WB	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-216	Afuco™ Anti-TNFSF13B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-216)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody

CAT	Product Name	Application	Type
FN-008CQ	Rat Anti-TNFSF13B Recombinant Antibody (FN-008CQ)	ELISA, FuncS, IP	Rat IgG2a
HPAB-1877LY	Human Anti-TNFSF13B Recombinant Antibody (HPAB-1877LY)	Inhib	Human IgG
VS-0723-WK223	Rabbit Anti-TNFSF13B Recombinant Antibody (VS-0723-WK223)	ELISA, FC	Rabbit IgG
VS-0824-CJ2	Mouse Anti-TNFSF13B Recombinant Antibody (clone 2-1G11)	ELISA, FC, Inhib	Mouse IgG
VS7-0425-WR1026	Mouse Anti-TNFSF13B Recombinant Antibody (clone 6C3A2)	WB, ICC, FC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0724-YC1350	AbPlus™ Anti-TNFSF13B Magnetic Beads (VS-0724-YC1350)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY47	Human Anti-TNFSF13B (clone 10B1) scFv-Fc Chimera	ELISA, Neut	Human IgG1, scFv-Fc
VS-0125-FY48	Human Anti-TNFSF13B (clone 1B5) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc
VS-0425-FY68	Human Anti-TNFSF13B scFv-Fc Chimera (VS-0425-FY68)	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY226	CytoStream™ Mouse Anti-TNFSF13B Recombinant Antibody (clone H32-411)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC601	Recombinant Anti-TNFSF13B Vesicular Antibody, EV Displayed (VS-0425-YC601)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY7394	Anti-TNFSF13B Immunohistochemistry Kit	IHC

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