Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • TNFRSF8
  • Anti-CD30 (CA10)-β-glucuronide-Camptothecin Analog ADC

Anti-CD30 (CA10)-β-glucuronide-Camptothecin Analog ADC (CAT#: ADC-047LCT)

This ADC product is composed of an anti-CD30 antibody (clone cAC10) conjuagated via a β-glucuronide linker to Camptothecin Analog (cAC10-β-glucuronide-Camptothecin Analog). It has demonstrated a response in HL and ALCL treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Figure 4 IHC staining of human tonsil
Figure 4 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Figure 5 IF staining of human cell line EFO-21
Figure 5 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Figure 6 IF staining of human cell line K-562
Figure 6 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Figure 8 Appendix
Figure 8 Appendix
(Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

Specifications

  • Antibody Overview
  • Murine/Human Chimeric CD30-specific monoclonal Antibody cAC10
  • Clone
  • cAC10
  • Linker
  • β-glucuronide linker
  • Linker Class/Description
  • β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
  • Drug
  • Camptothecin Analog
  • Drug Class/Description
  • Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

Target

  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone cAC10"

See other products for "TNFRSF8"

Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products Chimeric Antibody Products Immunotoxin Products Humanized Antibody Products Fc Glycosylation Antibody Products Low- or Non-fucosylated Oligosaccharide Antibody Products IgG Antibody Products Chicken IgY Antibody Products Blocking Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products ADCC Enhanced Antibody Products Agonistic Antibody Products ScFv-Fc Chimera Products Flow Cytometry (FC) related Products
CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Customer Reviews and Q&As

Submit a review or a question

There are currently no Customer reviews or questions for ADC-047LCT. Click the button above to contact us or submit your feedback about this product.

Popular products with customers

Figure 1 Anti-ANGPT2 Therapeutic Antibody (TAB-769) in DB

Anti-ANGPT2 Recombinant Antibody (CAT# TAB-769)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human CD40L Recombinant Antibody (TAB-027) in SDS-PAGE

Anti-Human CD40L Recombinant Antibody (TAB-027) (CAT# TAB-027)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human IL6 Recombinant Antibody (TAB-097) in ELISA

Anti-Human IL6 Recombinant Antibody (Sirukumab) (CAT# TAB-097)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Figure 1 Anti-Human IL1 beta Recombinant Antibody (TAB-161) in SDS-PAGE

Anti-Human IL1 beta Recombinant Antibody (TAB-161) (CAT# TAB-161)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human FLT3 Therapeutic Antibody (TAB-291CL) in DB

Anti-Human FLT3 Recombinant Antibody (IMC-EB10) (CAT# TAB-291CL)
Application: WB, IHC, FC, Cyt, ELISA

Figure 1 Anti-Human HSP90 Recombinant Antibody (TAB-368CL) in WB

Anti-Human HSP90 Recombinant Antibody (CAT# TAB-368CL)
Application:

Figure 1 Anti-Human MET Recombinant Antibody (TAB-521CL) in ELISA

Anti-Human MET Recombinant Antibody (TAB-521CL) (CAT# TAB-521CL)
Application: WB, FuncS

Figure 1 Anti-Human C5 Recombinant Antibody (TP-092CL) in SDS-PAGE

Human Anti-Human C5 Rcombinant Antibody (TP-092CL) (CAT# TP-092CL)
Application:

Figure 1 Human IgG4 Isotype Control Antibody (MOB-0408ZL) in SDS-PAGE

Human IgG4 Isotype Control Antibody (CAT# MOB-0408ZL)
Application: ELISA, IB, FC, IHC, FuncS

Figure 1 Recombinant Human Anti-IAV HA Antibody (PABL-214) in SDS-PAGE

Recombinant Human Anti-IAV HA Antibody (FI6V3) (CAT# PABL-214)
Application: WB, IHC, FuncS

Figure 1 Anti-Human CEACAM5 Recombinant Antibody (PABL-496) in SDS-PAGE

Recombinant Mouse Anti-HCV E2 Antibody (AP33) (CAT# PABL-496)
Application: FC, Neut, FuncS

Figure 1 Anti-Kallikrein-2 Recombinant Antibody (TAB-0622CL) in SDS-PAGE

Mouse Anti-KLK2 Recombinant Antibody (TAB-0622CL) (CAT# TAB-0622CL)
Application: FuncS, IF

Figure 1 Human Anti-CD3 Recombinant Antibody (TAB-0416CL-S(P)) in SDS-PAGE

Mouse Anti-CD3 Recombinant Antibody scFv Fragment (TAB-0416CL-S(P)) (CAT# TAB-0416CL-S(P))
Application: IB, ELISA, FC, FuncS

Figure 1 Anti-FCRN Antibody in WB.

Human Anti-FCRN Recombinant Antibody; Fab Fragment (TAB-0145CL-F(E)) (CAT# TAB-0145CL-F(E))
Application: ELISA, FC, Block, SPR

Figure 1 Anti-Human MUC1 Therapeutic Antibody (TAB-418MZ) in DB

Mouse Anti-MUC1 Recombinant Antibody (TAB-418MZ) (CAT# TAB-418MZ)
Application: ELISA, FuncS, IHC, IF, FC, ADCC

Figure 1 Human Anti-Human ERBB3 Antibody (TAB-422CQ) in WB

Anti-Human ERBB3 Recombinant Antibody (TAB-422CQ) (CAT# TAB-422CQ)
Application: ELISA, IHC, FC, IP, IF, BL

Figure 1 Recombinant Human Anti-WTA Antibody (HPAB-N0298-YC) in SDS-PAGE

Human Anti-WTA Recombinant Antibody (HPAB-N0298-YC) (CAT# HPAB-N0298-YC)
Application: FuncS

Figure 1 Human Anti-FRβ Recombinant Antibody (m909) (HPAB-0792-FY) in WB.

Human Anti-FRβ Recombinant Antibody (HPAB-0792-FY) (CAT# HPAB-0792-FY)
Application: ELISA

Figure 1 Mouse Anti-IL17RB Recombinant Antibody (HPAB-AP684-YC) in DB

Mouse Anti-IL17RB Recombinant Antibody (HPAB-AP684-YC) (CAT# HPAB-AP684-YC)
Application: Neut, FuncS, IHC, ELISA, FC, Inhib

Figure 1 Human Anti-APS Recombinant Antibody (clone CL1) (HPAB-1960-FY) in SDS-PAGE

Human Anti-APS Recombinant Antibody (clone CL1) (CAT# HPAB-1960-FY)
Application: ELISA, Activ, Block

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare