Anti-CD30 receptorc (AC10)-mc-MMAF ADC (CAT#: ADC-054LCT)

• Antibody Overview
• Murine/Human Chimeric CD30-specific monoclonal Antibody cAC10

• Clone
• cAC10

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Alternative Names
• TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;

• Gene ID
• 943

• UniProt ID
• A5D8T4

• ADC-038LCT
• Anti-CD30 (brentuximab)-DIBO-doxorubicin ADC

• ADC-039LCT
• Anti-CD30 (cAC10)-vcMMAE ADC

• ADC-040LCT
• Anti-CD30 (cAC10)-MC-PABC-MMAE ADC

• ADC-124LCT
• Anti-CD30 (cAC10)-DIBO-doxorubicin ADC

• ADC-064LZY
• Anti-CD30 (clone cAc10)-vc-PABC-MMAE ADC

• ADC-041LCT
• Anti-CD30 (cAC10)-mc-vc-MMAE ADC

• ADC-008LZY
• Anti-CD30 (clone cAC10)-vc-PAB-MMAE ADC

• ADC-156LZY
• Anti-CD30 (clone cAC10)-mc-vc-PABC-MMAE ADC

• ADC-042LCT
• Anti-CD30 (cAC10)-MC-VC-PABC-MMAE ADC

• ADC-024LZY
• Anti-CD30 (clone cAC10)-vc-MMAE ADC

• ADC-043LCT
• Anti-CD30 (cAC10)-vc-MMAF ADC

• ADC-044LCT
• Anti-CD30 (cAC10)-vc-PABC-MMAE ADC

• ADC-045LCT
• Anti-CD30 (hCA10)-α-glucuronide-MMAE ADC

• ADC-046LCT
• Anti-CD30 (hCA10)-α-glucuronide-MMAF ADC

• ADC-047LCT
• Anti-CD30 (CA10)-β-glucuronide-Camptothecin Analog ADC

Select a product category from the dropdown menu below to view related products.