Human Anti-IL1B (clone 9.5.2) scFv-Fc Chimera
CAT#: VS-0425-FY1
The Anti-IL1B scFv-Fc is a recombinant fusion protein designed to specifically bind and neutralize interleukin-1 beta (IL-1β), a key pro-inflammatory cytokine involved in various inflammatory diseases. This product combines a single-chain variable fragment (scFv) with the Fc region of an immunoglobulin, enhancing its stability, serum half-life, and binding affinity.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B
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Specifications
- Immunogen
- Recombinant human IL-1β as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL1B
- Species Reactivity
- Human, Cynomolgus monkey
- Clone
- 9.5.2
- Applications
- Neutralization, ELISA
- Related Disease
- Rheumatoid arthritis, osteoarthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 2 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 1 Beta
- Gene ID
- 3553
- UniProt ID
- P01584
- Long Name
- Interleukin 1 Beta
- Cellular Localization
- Cytoplasm, Lysosome, Secreted
- Function
- The IL1B gene encodes interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine crucial for the body's immune response. Produced mainly by activated macrophages, IL-1β plays a key role in initiating and amplifying inflammation. It induces fever, stimulates the production of acute-phase proteins, and promotes the activation and recruitment of immune cells like neutrophils and lymphocytes.
Furthermore, IL-1β influences the proliferation and differentiation of various cells and can contribute to tissue remodeling by inducing the production of enzymes and prostaglandins. While essential for host defense against pathogens and injury, dysregulation of IL-1β is implicated in numerous inflammatory and autoimmune diseases. The mature form of IL-1β is processed and secreted via a specific pathway involving caspase-1 and gasdermin-D.
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Related Diseases
Rheumatoid Arthritis
Maturity Onset Diabetes of the Young
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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