Anti-Human IL1Beta Recombinant Antibody (Canakinumab) (CAT#: TAB-021)

Recombinant monoclonal antibody to Human IL1 beta. Canakinumab is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.

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ELISA

Figure 1 Human IL1 Beta Therapeutic Antibody (TAB-021) in ELISA

Figure 1 Human IL1 Beta Therapeutic Antibody (TAB-021) in ELISA

ELISA analysis of TAB-021 was performed by coating with Recombinant Human IL1 Beta.

WB

Figure 2 Human IL1 Beta Therapeutic Antibody (TAB-021) in WB

Figure 2 Human IL1 Beta Therapeutic Antibody (TAB-021) in WB

Western blot analysis of TAB-021 was performed with Recombinant Human IL1 Beta.
Lane 1: Non-Reducing Antigen (1ug)
Lane 2: Reducing Antigen (1ug)


Specifications

  • Immunogen
  • Recombinant human ILI beta
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
  • CAS
  • 914613-48-2
  • Generic Name
  • Canakinumab
  • ATC Code
  • L04AC08
  • DrugBank
  • DB06168
  • UNII
  • 37CQ2C7X93
  • ChEMBL
  • CHEMBL1201834
  • MW
  • 145.2 kDa
  • Related Disease
  • Rheumatoid arthritis (RA)

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

  • Alternative Names
  • Canakinumab;914613-48-2;ACZ885;DB06168Catabolin;H1;Hematopoietin 1;IFN beta inducing factor;IL 1;IL 1 beta;IL 1B;IL-1 beta;IL1 BETA;IL1F2;Interleukin 1 beta;Interleukin 1 beta precursor;Interleukin-1 beta;LAF;OAF;Osteoclast activating factor;OTTHUM

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Canakinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Canakinumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Canakinumab"

Afuco™ Anti-IL1B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-021)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL1 beta. It is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
DrugMonitor™ Anti-Canakinumab Antibody (VS-1224-YC249)
Canakinumab is a recombinant anti-human IL-1β monoclonal antibody marketed for treating Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS). The DrugMonitor™ Anti-Canakinumab Antibody (VS-1224-YC249) is an anti-drug antibody (ADA) against Canakinumab. This drug-based antibody is raised in mice immunized with the Canakinumab. The anti-Canakinumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Canakinumab in samples.

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To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-021, RRID: AB_3111754)

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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