Afuco™ Anti-IL1B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-161)

Name: Afuco™ Anti-IL1B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-161)
SKU: AFC-TAB-161
Rating: 5 (1 reviews)

CAT#: AFC-TAB-161

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL1 beta. It is a humanized monoclonal antibody used in the treatment of diabetes and inflammatory disorders.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced.

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125538-IL1B

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Antibody Isotype
IgG2, κ

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut

Conjugate
Unconjugated

Generic Name
Gevokizumab

Related Disease
Cardiovascular disease

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA;

Gene ID
3553

UniProt ID
P01584

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Biosimilar Overview

Please refer to Gevokizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Gevokizumab.

Related Diseases

Rheumatoid Arthritis

Maturity Onset Diabetes of the Young

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-161.pdf

MSDS

MSDS - AFC-TAB-161.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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Gevokizumab has been trialed for conditions like acne vulgaris, osteoarthritis, Behcet's uveitis, pyoderma gangrenosum, and Behcet's disease uveitis, acting as a modulator of cytokine imbalance in IL-1 mediated states with high binding affinity. The DrugMonitor™ Anti-Gevokizumab Antibody (VS-1224-YC518) is an anti-drug antibody (ADA) against Gevokizumab. This drug-based antibody is raised in mice immunized with the Gevokizumab. The anti-Gevokizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Gevokizumab in samples.

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