Recombinant Mouse Anti-ENG Antibody (clone 2B2H2)

CAT#: VS3-FY232

This product is a recombinant mouse antibody that recognizes ENG protein. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IHC staining of human placenta Figure 3 IF staining of human cell line BJ Figure 4 IF staining of human cell line SiHa Figure 5 Kidney Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)

Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • ENG
  • Clone
  • 2B2H2
  • Applications
  • Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry
  • Conjugate
  • Unconjugated

Product Property

  • Purity
  • >95%
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry.

Target

  • Alternative Names
  • Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1
  • Cellular Localization
  • Cell membrane, Membrane
  • Function
  • Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
    Required for normal structure and integrity of adult vasculature (PubMed:7894484).
    Regulates the migration of vascular endothelial cells (PubMed:17540773).
    Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
    May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
    May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
    Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
    Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Secondary Antibody

Isotype Control

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