Recombinant Mouse Anti-ENG Antibody (clone 2B2H2) (CAT#: VS3-FY232)
This product is a recombinant mouse antibody that recognizes ENG protein. This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg
(Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg
Figure 3 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg
Figure 4 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- ENG
- Clone
- 2B2H2
- Applications
- Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry
- Conjugate
- Unconjugated
Product Property
- Purity
- >95%
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Western Blot, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1
- Gene ID
- 2022
- UniProt ID
- P17813
- Cellular Localization
- Cell membrane, Membrane
- Protein Refseq
- NP_000109.1; NP_001108225.1; NP_001265067.1
- Function
- Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
Required for normal structure and integrity of adult vasculature (PubMed:7894484).
Regulates the migration of vascular endothelial cells (PubMed:17540773).
Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ENG"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1569CL | Human Anti-ENG Recombinant Antibody (TAB-1569CL) | ELISA, FC | Human antibody |
| TAB-1571CL | Human Anti-ENG Recombinant Antibody (TAB-1571CL) | ELISA, FC | Human IgG1 |
| TAB-1577CL | Anti-Human ENG Recombinant Antibody (9H10) | FuncS | Fully human antibody |
| TAB-1577CL-S(P) | Anti-Human ENG Recombinant Antibody scFv Fragment (9H10) | FuncS | Fully human antibody |
| TAB-1577CL-F(E) | Anti-Human ENG Recombinant Antibody Fab Fragment (9H10) | FuncS | Fully human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1573CL | Mouse Anti-ENG Recombinant Antibody (TAB-1573CL) | FC, Apop | Mouse IgG |
| TAB-1573CL-S(P) | Mouse Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1573CL-S(P)) | FC, Apop | Mouse scFv |
| TAB-1574CL-S(P) | Mouse Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1574CL-S(P)) | FC | Mouse scFv |
| TAB-1573CL-F(E) | Mouse Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1573CL-F(E)) | FC, Apop | Mouse Fab |
| TAB-1574CL-F(E) | Mouse Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1574CL-F(E)) | FC | Mouse Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1575CL | Human Anti-ENG Recombinant Antibody (TAB-1575CL) | Apop | Humanized antibody |
| TAB-1575CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1575CL-S(P)) | Apop | Human scFv |
| TAB-1576CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1576CL-S(P)) | Cyt, ELISA, FC, FuncS | Human scFv |
| TAB-1575CL-F(E) | Human Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1575CL-F(E)) | Apop | Humanized Fab |
| TAB-1576CL-F(E) | Human Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1576CL-F(E)) | Cyt, ELISA, FC, FuncS | Humanized Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0293MZ | Recombinant Mouse Anti-Human Endoglin Antibody (clone TN7h) | IHC | Mouse antibody |
| HPAB-0231-YC | Human Anti-ENG Recombinant Antibody (clone Vκ2VH1) | ELISA, WB, FuncS | Humanized IgG |
| HPAB-0162CQ | Mouse Anti-ENG Recombinant Antibody (clone E9) | ELISA, WB, FC, IHC, IHC-Fr, IP | Mouse IgG1 |
| FN-061CQ | Mouse Anti-ENG Recombinant Antibody (clone SN6) | FC, FuncS, IHC | Mouse IgG1, κ |
| VS3-WK168 | Mouse Anti-ENG Recombinant Antibody (clone H4-A9) | WB, ELISA | Mouse IgG1 |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0189MZ | Chicken Anti-Endoglin Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-726CQ | Mouse Anti-ENG Recombinant Antibody (clone 7D11) | WB, Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1150 | Hi-Affi™ Rabbit Anti-ENG Recombinant Antibody (clone DS1150AB) | WB, IHC-P, IP, FC | Rabbit IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-013ML | Anti-Human ENG Recombinant Antibody (Carotuximab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0231-YC-S(P) | Human Anti-ENG Recombinant Antibody (clone Vκ2VH1); scFv Fragment | ELISA, WB, FuncS | Humanized scFv |
| HPAB-0713-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 6B10); scFv Fragment | WB, FC | Human scFv |
| HPAB-0714-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 4.120); scFv Fragment | WB, FC | Human scFv |
| HPAB-0715-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 4.37); scFv Fragment | WB, FC | Human scFv |
| HPAB-0137-WJ-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (HPAB-0137-WJ-S(P)) | ELISA | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0713-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 6B10); Fab Fragment | WB, FC | Human Fab |
| HPAB-0714-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 4.120); Fab Fragment | WB, FC | Human Fab |
| HPAB-0715-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 4.37); Fab Fragment | WB, FC | Human Fab |
| HPAB-AP642-YC-F(E) | Human Anti-ENG Recombinant Antibody (clone Vκ1VH1); Fab Fragment | ELISA | Humanized Fab |
| HPAB-AP644-YC-F(E) | Human Anti-ENG Recombinant Antibody (clone Vκ2VH2); Fab Fragment | ELISA | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-013ML | Afuco™ Anti-ENG ADCC Recombinant Antibody (Carotuximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0613 | PE-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0614 | APC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0615 | FITC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0616 | A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0707-YJ-VHH | Camelid Anti-ENG Recombinant Single Domain Antibody (HPAB-0707-YJ-VHH) | ELISA, ICC | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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