Recombinant Anti-IL3RA Vesicular Antibody, EV Displayed (VS-0425-YC104)
CAT#: VS-0425-YC104
The Recombinant Anti-IL3RA Vesicular Antibody, EV Displayed (VS-0425-YC104) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL3RA-expressed cells or tissues. The IL3RA is a component of the interleukin 3 receptor, crucial for cytokine receptor functions and IL3-related activities.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185291-IL3RA
❮
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Recombinant Antibody
- Application
- Cyt, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL3RA
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 3 receptor subunit alpha
- Molecular Function
- Receptor
- Introduction
- The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
- Alternative Names
- CD123
- Gene ID
- 3563
- UniProt ID
- P26951
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-663LC | Mouse Anti-IL3RA Recombinant Antibody (TAB-663LC) | ELISA, FC, Cyt | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1345LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1345LY-S(P)) | ELISA | Human scfv |
| HPAB-1346LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1346LY-S(P)) | ELISA | Human scfv |
| HPAB-1348LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1348LY-S(P)) | ELISA | Human scfv |
| HPAB-1349LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1349LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1884LY-F(E) | Mouse Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1884LY-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-1885LY-F(E) | Mouse Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1885LY-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-1886LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1886LY-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-1887LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1887LY-F(E)) | ELISA, Inhib | Humanized Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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|---|---|---|---|
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