IL3-PE immunotoxin
CAT#: AGTO-L009E
This immunotoxin was achieved by conjugating/fusing the IL3 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of leukemia.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3539/11801_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185291-IL3RA
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Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- IL3-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Leukemia
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G044E | IL-3-PE immunotoxin | Cytotoxicity assay, Function study | |
| AGTO-G044D | IL-3-DT immunotoxin | Cytotoxicity assay, Function study | |
| AGTO-G045E | Anti-IL3RA immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G045D | Anti-IL3RA immunotoxin (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-L009D | IL3-DT immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-663LC | Mouse Anti-IL3RA Recombinant Antibody (TAB-663LC) | ELISA, FC, Cyt | Mouse IgG |
| TAB-664LC | Mouse Anti-IL3RA Recombinant Antibody (TAB-664LC) | ELISA, FC, Cyt | Mouse IgG |
| TAB-665LC | Mouse Anti-IL3RA Recombinant Antibody (TAB-665LC) | ELISA, FC, Cyt | Mouse IgG |
| TAB-663LC-F(E) | Mouse Anti-IL3RA Recombinant Antibody; Fab Fragment (TAB-663LC-F(E)) | ELISA, FC | Mouse Fab |
| TAB-664LC-F(E) | Mouse Anti-IL3RA Recombinant Antibody; Fab Fragment (TAB-664LC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1396CQ | Mouse Anti-IL3RA Recombinant Antibody (clone CBL452) | WB, FC, IHC, CyTOF, ICC, Neut | Mouse IgG1 |
| NEUT-1397CQ | Mouse Anti-IL3RA Recombinant Antibody (clone MM0403-11A23) | WB, Neut, IHC, IHC-Fr | Mouse IgG1 |
| NEUT-1398CQ | Mouse Anti-IL3RA Recombinant Antibody (clone CBL122) | Neut, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4272 | Rabbit Anti-IL3RA Recombinant Antibody (clone SI355DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1344LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1344LY-S(P)) | ELISA | Human scfv |
| HPAB-1345LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1345LY-S(P)) | ELISA | Human scfv |
| HPAB-1346LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1346LY-S(P)) | ELISA | Human scfv |
| HPAB-1348LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1348LY-S(P)) | ELISA | Human scfv |
| HPAB-1349LY-S(P) | Human Anti-IL3RA Recombinant Antibody; scFv Fragment (HPAB-1349LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1344LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1344LY-F(E)) | ELISA | Human Fab |
| HPAB-1345LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1345LY-F(E)) | ELISA | Human Fab |
| HPAB-1346LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1346LY-F(E)) | ELISA | Human Fab |
| HPAB-1348LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1348LY-F(E)) | ELISA | Human Fab |
| HPAB-1349LY-F(E) | Human Anti-IL3RA Recombinant Antibody; Fab Fragment (HPAB-1349LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0143-YC | Human Anti-IL3RA Recombinant Antibody (HPAB-J0143-YC) | FC | Human IgG |
| HPAB-J0144-YC | Human Anti-IL3RA Recombinant Antibody (HPAB-J0144-YC) | FC | Human IgG |
| HPAB-J0145-YC | Human Anti-IL3RA Recombinant Antibody (HPAB-J0145-YC) | FC | Human IgG |
| HPAB-J0146-YC | Human Anti-IL3RA Recombinant Antibody (HPAB-J0146-YC) | FC | Human IgG |
| HPAB-J0147-YC | Human Anti-IL3RA Recombinant Antibody (HPAB-J0147-YC) | FC, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1513 | AbPlus™ Anti-IL3RA Magnetic Beads (VS-0724-YC1513) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC48 | Rabbit Anti-IL3RA Antibody (VS-0924-YC48) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY140 | CytoStream™ Mouse Anti-IL3RA Recombinant Antibody (VS-0225-XY140) | FC | Mouse IgG1, kappa |
| VS-0225-XY139 | CytoStream™ Mouse Anti-IL3RA Recombinant Antibody (VS-0225-XY139) | FC, IF, WB | Mouse IgG1, kappa |
| VS13-YC581 | CytoStream™ Rabbit Anti-IL3RA Recombinant Antibody (VS13-YC581) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY68 | Human Anti-IL3RA (clone Talacotuzumab) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC104 | Recombinant Anti-IL3RA Vesicular Antibody, EV Displayed (VS-0425-YC104) | Cyt, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3530 | Anti-IL3RA Immunohistochemistry Kit | IHC |
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