IL-3-PE immunotoxin (CAT#: AGTO-G044E)

This immunotoxin was achieved by conjugating/fusing the IL-3 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL3RA expressing leukemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating leukemia.


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Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • IL-3-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Leukemia

Target

  • Alternative Names
  • IL3RA; interleukin 3 receptor, alpha (low affinity); IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; interleukin-3 receptor subunit alpha; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE70

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IL3RA"

Immunotoxin

CAT Product Name Application Type
AGTO-G044D IL-3-DT immunotoxin Cytotoxicity assay, Function study
AGTO-G045E Anti-IL3RA immunotoxin 26292 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G045D Anti-IL3RA immunotoxin 26292 (scFv)-DT Cytotoxicity assay, Function study
AGTO-L009E IL3-PE immunotoxin Cytotoxicity assay, Functional assay
AGTO-L009D IL3-DT immunotoxin Cytotoxicity assay, Functional assay

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1396CQ Mouse Anti-IL3RA Recombinant Antibody (clone CBL452) WB, FC, IHC, CyTOF, ICC, Neut Mouse IgG1
NEUT-1397CQ Mouse Anti-IL3RA Recombinant Antibody (clone MM0403-11A23) WB, Neut, IHC, IHC-Fr Mouse IgG1
NEUT-1398CQ Mouse Anti-IL3RA Recombinant Antibody (clone CBL122) Neut, WB, IHC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4272 Rabbit Anti-IL3RA Recombinant Antibody (clone SI355DS) ELISA Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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