Recombinant Anti-TEK Vesicular Antibody, EV Displayed (VS-0425-YC649)
CAT#: VS-0425-YC649
The Recombinant Anti-TEK Vesicular Antibody, EV Displayed (VS-0425-YC649) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TEK-expressed cells or tissues. TEK is a tyrosine kinase receptor involved in embryonic vascular development, associated with venous malformations.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TEK
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TEK receptor tyrosine kinase
- Biological Process
- Angiogenesis
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane, Centrosome, Basal body
- Introduction
- This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
- Alternative Names
- CD202b, TIE-2, TIE2, VMCM, VMCM1
- Gene ID
- 7010
- UniProt ID
- Q02763
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1030 | Mouse Anti-TEK Recombinant Antibody (clone YC183); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0418-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0418-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0419-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0419-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0420-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0420-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-S0139-YC-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 12H8); Fab Fragment | ELISA, Antagonist | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B064(A) | Recombinant Anti-human TEK Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B064(G) | Recombinant Anti-human TEK Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B064(T) | Recombinant Anti-human TEK Intrabody [Tat] | ELISA, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-655CT-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (TAB-655CT-S(P)) | ELISA | Human scFv |
| TAB-656CT-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (TAB-656CT-S(P)) | ELISA | Human scFv |
| TAB-657CT-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (TAB-657CT-S(P)) | ELISA | Human scFv |
| TAB-658CT-S(P) | Human Anti-TEK Recombinant Antibody (TAB-658CT-S(P)); scFv Fragment | ELISA | Human scFv |
| TAB-655CT-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (TAB-655CT-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0758MZ | Chicken Anti-TIE2 Polyclonal IgY | ELISA, IHC, IP, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1993CQ | Recombinant Mouse Anti-tek Antibody (CBL344) | BL, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3530 | Rabbit Anti-TEK Recombinant Antibody (clone DS3530AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-254CQ | Rat Anti-TEK Recombinant Antibody (clone TEK4) | FC, FuncS, IHC-Fr | Rat IgG1, κ |
| HPAB-0066-YJ | Recombinant Mouse Anti-TEK Antibody (12H8) | Immunoassay, WB | Mouse IgG, κ |
| HPAB-0418-WJ | Human Anti-TEK Recombinant Antibody (HPAB-0418-WJ) | ELISA, FC, FuncS | Human IgG |
| HPAB-S0139-YC | Mouse Anti-TEK Recombinant Antibody (clone 12H8) | ELISA, Antagonist | Mouse IgG |
| HPAB-S0140-YC | Mouse Anti-TEK Recombinant Antibody (clone 6A3) | ELISA, Antagonist | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0418-WJ-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-0418-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0419-WJ-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-0419-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0420-WJ-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-0420-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-J0235-YC-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-J0235-YC-S(P)) | ELISA, Inhib, FuncS | Human scFv |
| HPAB-J0236-YC-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-J0236-YC-S(P)) | ELISA, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY76 | Mouse Anti-TEK (clone 12H8) scFv-Fc Chimera | Antagonist | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7167 | Anti-TEK Immunohistochemistry Kit | IHC |
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