Recombinant Anti-human TEK Intrabody [(D-Arg)9] (CAT#: IAB-B064(A))
Recombinant anti-TEK intrabody linked to (D-Arg)9 works within cells to bind human TEK, expressed in E. coli cells.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Figure 3 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Figure 4 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Figure 6 Testis
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120156-TEK
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120156-TEK
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
Specifications
- Immunogen
- human TEK tyrosine kinase, endothelial
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Protein fragment complementation; Neutralization; Functional studies
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; angiopoietin-1 receptor; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine k
- Gene ID
- 7010
- UniProt ID
- Q02763
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B064(G) | Recombinant Anti-human TEK Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B064(T) | Recombinant Anti-human TEK Intrabody [Tat] | ELISA, ICC, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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