Mouse Anti-TEK (clone 12H8) scFv-Fc Chimera
CAT#: VS-0325-FY76
The anti-TEK scFv-Fc antibody targets TEK (TIE2), a receptor tyrosine kinase involved in angiogenesis and vascular development. It can modulate TEK signaling pathways, making it a potential tool for studying vascular biology and related diseases. The scFv-Fc format enhances its stability and bioavailability, allowing for prolonged action in vivo.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
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Specifications
- Immunogen
- Recombinant Tie2 extracellular domain-Fc fusion
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human TEK
- Species Reactivity
- Human
- Clone
- 12H8
- Applications
- Antagonist
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- TEK Receptor Tyrosine Kinase; Tyrosine Kinase With Ig And EGF Homology Domains-2; Tunica Interna Endothelial Cell Kinase; Tyrosine-Protein Kinase Receptor TIE-2; Tyrosine-Protein Kinase Receptor TEK; TEK Tyrosine Kinase, Endothelial; Endothelial Tyrosine Kinase; EC 2.7.10.1; VMCM1; VMCM; TIE2
- Gene ID
- 7010
- UniProt ID
- Q02763
- Long Name
- TEK Receptor Tyrosine Kinase
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane; Cell junction; Cell junction, focal adhesion; Cytoplasm, cytoskeleton; Secreted
- Post Translation Modifications
- Ubiquitinated.
The phosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Glycosylation at Asn140, Asn158, Asn399, Asn438, Asn464, Asn560, Asn596, Asn649, Asn691, and Asn1104
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect TIE2_HUMAN (769)
Glycosylation from GlyGen 10 sites, 12 N-linked glycans (6 sites)
- Protein Refseq
- NP_000450.3; NP_001277006.2; NP_001277007.2; NP_001362404.1; NP_001362405.1
- Function
- TEK (Tyrosine kinase, endothelial) also known as Tie2, is a receptor tyrosine kinase that plays a crucial role in angiogenesis and vascular development. It is essential for blood vessel formation and maintenance.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
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- Product Name
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- CAT
- Product Name
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Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1030 | Mouse Anti-TEK Recombinant Antibody (clone YC183); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0564-CN-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 15B8); Fab Fragment | ELISA, Agonist | Mouse Fab |
| HPAB-0565-CN-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 13H10); Fab Fragment | ELISA, Agonist | Mouse Fab |
| HPAB-0066-YJ-F(E) | Recombinant Mouse Anti-TEK Antibody Fab Fragment (12H8) | Immunoassay, WB | Mouse Fab |
| HPAB-S0139-YC-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 12H8); Fab Fragment | ELISA, Antagonist | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B064(A) | Recombinant Anti-human TEK Intrabody [(D-Arg)9] | PCA, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B064(G) | Recombinant Anti-human TEK Intrabody [+36 GFP] | WB, Neut, FuncS | scFv-(+36GFP) |
| IAB-B064(T) | Recombinant Anti-human TEK Intrabody [Tat] | ELISA, ICC, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-655CT | Human Anti-TEK Recombinant Antibody (TAB-655CT) | ELISA | Human IgG |
| TAB-655CT-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (TAB-655CT-F(E)) | ELISA | Human Fab |
| TAB-656CT-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (TAB-656CT-F(E)) | ELISA | Human Fab |
| TAB-657CT-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (TAB-657CT-F(E)) | ELISA | Human Fab |
| TAB-658CT-F(E) | Human Anti-TEK Recombinant Antibody (TAB-658CT-F(E)); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0758MZ | Chicken Anti-TIE2 Polyclonal IgY | ELISA, IHC, IP, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1993CQ | Recombinant Mouse Anti-tek Antibody (CBL344) | BL, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3530 | Rabbit Anti-TEK Recombinant Antibody (clone DS3530AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0564-CN-S(P) | Mouse Anti-TEK Recombinant Antibody (clone 15B8); scFv Fragment | ELISA, Agonist | Mouse scFv |
| HPAB-0565-CN-S(P) | Mouse Anti-TEK Recombinant Antibody (clone 13H10); scFv Fragment | ELISA, Agonist | Mouse scFv |
| HPAB-0066-YJ-S(P) | Recombinant Mouse Anti-TEK Antibody scFv Fragment (12H8) | Immunoassay, WB | Mouse scFv |
| HPAB-0418-WJ-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-0418-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0419-WJ-S(P) | Human Anti-TEK Recombinant Antibody; scFv Fragment (HPAB-0419-WJ-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-YJ | Recombinant Mouse Anti-TEK Antibody (12H8) | Immunoassay, WB | Mouse IgG, κ |
| HPAB-0418-WJ | Human Anti-TEK Recombinant Antibody (HPAB-0418-WJ) | ELISA, FC, FuncS | Human IgG |
| HPAB-J0235-YC | Human Anti-TEK Recombinant Antibody (HPAB-J0235-YC) | ELISA, Inhib, FuncS | Human IgG1 |
| HPAB-J0236-YC | Human Anti-TEK Recombinant Antibody (HPAB-J0236-YC) | ELISA, Inhib, FuncS | Human IgG4 |
| HPAB-J0237-YC | Human Anti-TEK Recombinant Antibody (HPAB-J0237-YC) | ELISA, Inhib, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC649 | Recombinant Anti-TEK Vesicular Antibody, EV Displayed (VS-0425-YC649) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7167 | Anti-TEK Immunohistochemistry Kit | IHC |
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