Recombinant Anti-human TEK Intrabody [Tat]

Name: Recombinant Anti-human TEK Intrabody [Tat]
SKU: IAB-B064(T)
Rating: 5 (1 reviews)

CAT#: IAB-B064(T)

Recombinant anti-TEK intrabody in fusion with HIV Tat works within cells to bind human TEK, expressed in E. coli cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line AF22

Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg

Normal Tissue Figure 5 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg

Normal Tissue Figure 6 Testis

Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK

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Specifications

Immunogen
human TEK tyrosine kinase, endothelial

Host Species
human

Type
scFv-Tat

Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

Species Reactivity
human

Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies

Product Property

Purity
>95%, by SDS-PAGE with Coomassie Brilliant Blue staining

Storage
4°C or -20°C, avoid repeated freezing and thawing.

Target

Alternative Names
TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; angiopoietin-1 receptor; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine k

Gene ID
7010

UniProt ID
Q02763

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - IAB-B064(T).pdf

MSDS

MSDS - IAB-B064(T).pdf

COA

Certificate of Analysis Lookup

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