Recombinant Anti-human TEK Intrabody [Tat]
CAT#: IAB-B064(T)
Recombinant anti-TEK intrabody in fusion with HIV Tat works within cells to bind human TEK, expressed in E. coli cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK
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Specifications
- Immunogen
- human TEK tyrosine kinase, endothelial
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Target
- Alternative Names
- TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; angiopoietin-1 receptor; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine k
- Gene ID
- 7010
- UniProt ID
- Q02763
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0564-CN-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 15B8); Fab Fragment | ELISA, Agonist | Mouse Fab |
| HPAB-0565-CN-F(E) | Mouse Anti-TEK Recombinant Antibody (clone 13H10); Fab Fragment | ELISA, Agonist | Mouse Fab |
| HPAB-0418-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0418-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0419-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0419-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0420-WJ-F(E) | Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-0420-WJ-F(E)) | ELISA, FC | Human Fab |
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