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    Recombinant Anti-human TEK Intrabody [Tat] (CAT#: IAB-B064(T))

    Recombinant anti-TEK intrabody in fusion with HIV Tat works within cells to bind human TEK, expressed in E. coli cells.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
    Figure 2 IHC staining of human testis
    Figure 2 IHC staining of human testis
    (Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
    Figure 3 IF staining of human cell line AF22
    Figure 3 IF staining of human cell line AF22
    (Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
    Figure 4 IF staining of human cell line BJ
    Figure 4 IF staining of human cell line BJ
    (Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
    Normal Tissue
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Elongated or late spermatids
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Leydig cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Pachytene spermatocytes
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Round or early spermatids
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Sertoli cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
    RNA Expression
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000120156-TEK
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
    Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK

    Specifications

    • Immunogen
    • human TEK tyrosine kinase, endothelial
    • Host Species
    • human
    • Type
    • scFv-Tat
    • Cell Penetrating Peptide
    • TAT
      TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
    • Species Reactivity
    • human
    • Applications
    • Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies

    Product Property

    • Purity
    • >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
    • Storage
    • 4°C or -20°C, avoid repeated freezing and thawing.

    Target

    • Alternative Names
    • TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; angiopoietin-1 receptor; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine k

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "TEK"

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    CAT Product Name Application Type
    DrMAB-1030 Mouse Anti-TEK Recombinant Antibody (clone YC183); Fab Fragment ELISA Mouse Fab
    HPAB-0564-CN-F(E) Mouse Anti-TEK Recombinant Antibody (clone 15B8); Fab Fragment ELISA, Agonist Mouse Fab
    HPAB-0565-CN-F(E) Mouse Anti-TEK Recombinant Antibody (clone 13H10); Fab Fragment ELISA, Agonist Mouse Fab
    HPAB-0066-YJ-F(E) Recombinant Mouse Anti-TEK Antibody Fab Fragment (12H8) Immunoassay, WB Mouse Fab
    HPAB-S0139-YC-F(E) Mouse Anti-TEK Recombinant Antibody (clone 12H8); Fab Fragment ELISA, Antagonist Mouse Fab

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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