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Recombinant Mouse Anti-TEK Antibody Fab Fragment (12H8) (CAT#: HPAB-0066-YJ-F(E))

This product is a recombinant mouse Fab that recognizes human TIE2. Mab reacts with the extracellular domain of TIE2 and functions as signal transduction modulators, angiopoietin-1 receptor (TEK, hTIE2) inhibitors, angiogenesis inhibitors. It is useful in Atherosclerosis Therapy and Oncolytic Drugs.


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  • Purity:
  • Gene Expression
  • Datasheet
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1607_D9_2_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/ihc_selected.jpg
Figure 3 IF staining of human cell line AF22
Figure 3 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1687_H4_1_red_green.jpg
Figure 4 IF staining of human cell line BJ
Figure 4 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73265/1667_D9_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_8_3.jpg
Figure 6 Testis
Figure 6 Testis
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10359/24108_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120156-TEK
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
Figure 7 RNA cell line category: Group enriched (HUVEC TERT2, NTERA-2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120156-TEK

Specifications

  • Immunogen
  • Mice (Fl hybrids of Balb/c and C57BL/6) were immunised subcutaneously with recombinant Tie2 extracellular domain-Fc fusion in RIBI adjuvant and boosted with the same.
  • Host Species
  • Mouse
  • Type
  • Mouse Fab
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • 12H8
  • Applications
  • Immunoassay, Western Blot
  • Related Disease
  • Atherosclerosis, Tumor

Target

  • Alternative Names
  • TEK Receptor Tyrosine Kinase; Tyrosine Kinase With Ig And EGF Homology Domains-2; Tunica Interna Endothelial Cell Kinase; Tyrosine-Protein Kinase Receptor TIE-2; Tyrosine-Protein Kinase Receptor TEK; TEK Tyrosine Kinase, Endothelial; Endothelial Tyrosine Kinase; EC 2.7.10.1; VMCM1; VMCM; TIE2; 12H8 MAb

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 12H8"

See other products for "TEK"

Intrabody

CAT Product Name Application Type
IAB-B064(A) Recombinant Anti-human TEK Intrabody [(D-Arg)9] PCA, Neut, FuncS scFv-(D-Arg)9
IAB-B064(G) Recombinant Anti-human TEK Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)
IAB-B064(T) Recombinant Anti-human TEK Intrabody [Tat] ELISA, ICC, FuncS scFv-Tat

Human Antibody

CAT Product Name Application Type
TAB-655CT Human Anti-TEK Recombinant Antibody (TAB-655CT) ELISA Human IgG
TAB-656CT Human Anti-TEK Recombinant Antibody (TAB-656CT) ELISA Human IgG
TAB-657CT Human Anti-TEK Recombinant Antibody (TAB-657CT) ELISA Human IgG
TAB-658CT Human Anti-TEK Recombinant Antibody (TAB-658CT) ELISA Human IgG
TAB-655CT-F(E) Human Anti-TEK Recombinant Antibody; Fab Fragment (TAB-655CT-F(E)) ELISA Human Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-2338MZ Recombinant Mouse Anti-Human TEK Antibody (clone Dm. 27) ELISA, FC, IHC-Fr, WB Mouse antibody
HPAB-0564-CN Mouse Anti-TEK Recombinant Antibody (clone 15B8) ELISA, Agonist Mouse IgG
HPAB-0565-CN Mouse Anti-TEK Recombinant Antibody (clone 13H10) ELISA, Agonist Mouse IgG
HPAB-J0235-YC Human Anti-TEK Recombinant Antibody (HPAB-J0235-YC) ELISA, Inhib, FuncS Human IgG1
HPAB-J0236-YC Human Anti-TEK Recombinant Antibody (HPAB-J0236-YC) ELISA, Inhib, FuncS Human IgG4

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0758MZ Chicken Anti-TIE2 Polyclonal IgY ELISA, IHC, IP, WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1993CQ Recombinant Mouse Anti-tek Antibody (CBL344) BL, WB IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3530 Rabbit Anti-TEK Recombinant Antibody (clone DS3530AB) WB, ICC, IF Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0564-CN-S(P) Mouse Anti-TEK Recombinant Antibody (clone 15B8); scFv Fragment ELISA, Agonist Mouse scFv
HPAB-0565-CN-S(P) Mouse Anti-TEK Recombinant Antibody (clone 13H10); scFv Fragment ELISA, Agonist Mouse scFv
HPAB-0066-YJ-S(P) Recombinant Mouse Anti-TEK Antibody scFv Fragment (12H8) Immunoassay, WB Mouse scFv
HPAB-S0139-YC-S(P) Mouse Anti-TEK Recombinant Antibody (clone 12H8); scFv Fragment ELISA, Antagonist Mouse scFv
HPAB-S0140-YC-S(P) Mouse Anti-TEK Recombinant Antibody (clone 6A3); scFv Fragment ELISA, Antagonist Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0564-CN-F(E) Mouse Anti-TEK Recombinant Antibody (clone 15B8); Fab Fragment ELISA, Agonist Mouse Fab
HPAB-0565-CN-F(E) Mouse Anti-TEK Recombinant Antibody (clone 13H10); Fab Fragment ELISA, Agonist Mouse Fab
HPAB-J0235-YC-F(E) Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-J0235-YC-F(E)) ELISA, Inhib, FuncS Human Fab
HPAB-J0236-YC-F(E) Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-J0236-YC-F(E)) ELISA, Inhib, FuncS Human Fab
HPAB-J0237-YC-F(E) Human Anti-TEK Recombinant Antibody; Fab Fragment (HPAB-J0237-YC-F(E)) ELISA, Inhib, FuncS Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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