Recombinant Anti-TSHR Vesicular Antibody, EV Displayed (VS-0425-YC579)
CAT#: VS-0425-YC579
The Recombinant Anti-TSHR Vesicular Antibody, EV Displayed (VS-0425-YC579) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TSHR-expressed cells or tissues. TSHR is a receptor central to thyroid cell metabolism, acting as a receptor for thyrotropin and thyrostimulin. Its activity is mediated by adenylate cyclase, with defects causing hyperthyroidism.
Gene Expression
Normal Tissue
Figure 1 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TSHR
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse, Rat, Cat, Dog, Sheep
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Thyroid stimulating hormone receptor
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- Alternative Names
- LGR3
- Gene ID
- 7253
- UniProt ID
- P16473
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Related Diseases
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-353 | Mouse Anti-TSHR Recombinant Antibody scFv Fragment (PSBL-353) | WB, ELISA, FuncS | Mouse scFv |
| FAMAB-0323CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody (clone 4G11); scFv Fragment | ELISA | Mouse scFv |
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| CAT | Product Name | Application | Type |
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| PFBL-730 | Human Anti-TSHR Recombinant Antibody Fab Fragment (PFBL-730) | Block | Human Fab |
| PFBW-172 | Human Anti-TSHR Recombinant Antibody (clone M22); Fab Fragment | WB | Human Fab |
| FAMAB-0323CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody (clone 4G11); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0324CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody (clone D2); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0367LY-F(E) | Human Anti-TSHR Recombinant Antibody (clone 5C9); Fab Fragment | Block, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-191CQ | Human Anti-TSHR Recombinant Antibody (TAB-191CQ) | ELISA, WB, Inhib | Human IgG |
| TAB-191CQ-S(P) | Human Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-191CQ-S(P)) | ELISA, WB, Inhib | Human scFv |
| TAB-191CQ-F(E) | Human Anti-TSHR Recombinant Antibody; Fab Fragment (TAB-191CQ-F(E)) | ELISA, WB, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-189CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-189CQ-S(P)) | ELISA, BL | Mouse scFv |
| TAB-190CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-190CQ-S(P)) | ELISA, BL | Mouse scFv |
| TAB-192CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-192CQ-S(P)) | ELISA, WB, Inhib | Mouse scFv |
| TAB-189CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody; Fab Fragment (TAB-189CQ-F(E)) | ELISA, BL | Mouse Fab |
| TAB-190CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody; Fab Fragment (TAB-190CQ-F(E)) | ELISA, BL | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2234CQ | Mouse Anti-TSHR Recombinant Antibody (clone 49) | Block, ELISA, ICC, IF, IP, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0323CQ | Mouse Anti-TSHR Recombinant Antibody (clone 4G11) | ELISA, Inhib | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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