Recombinant Anti-TSHR Vesicular Antibody, EV Displayed (VS-0425-YC579) (CAT#: VS-0425-YC579)

The Recombinant Anti-TSHR Vesicular Antibody, EV Displayed (VS-0425-YC579) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TSHR-expressed cells or tissues. TSHR is a receptor central to thyroid cell metabolism, acting as a receptor for thyrotropin and thyrostimulin. Its activity is mediated by adenylate cyclase, with defects causing hyperthyroidism.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Recombinant Antibody

  • Application
  • ELISA, FC, Neut, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • TSHR
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Mouse, Rat, Cat, Dog, Sheep
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Thyroid stimulating hormone receptor
  • Molecular Function
  • G-protein coupled receptor, Receptor, Transducer
  • Introduction
  • The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
  • Alternative Names
  • LGR3

Related Resources

  • Related Diseases

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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