Human Anti-TSHR Recombinant Antibody scFv Fragment (PSBL-730)
CAT#: PSBL-730
Recombinant Human Antibody scFv Fragment is specific to TSH receptor (TSHR), expressed in E. coli. The blocking autoantibody scFv fragment binds more N-terminally on the TSHR concave surface than either the stimulating autoantibody M22 or the hormone TSH, and this may reflect its different functional activity.
Gene Expression
Normal Tissue
Figure 1 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165409-TSHR
❮
❯
Specifications
- Immunogen
- Human thyroid stimulating hormone receptor
- Host Species
- Human
- Type
- Human scFv
- Specificity
- Human TSHR
- Species Reactivity
- Human
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
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Better specificity and affinity
The Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment has been a key component in our thyroid illness research. Its excellent specificity and affinity make our assays extremely trustworthy, while the smaller size of the scFv fragment improves tissue penetration for improved imaging.
Non-specific binding.
The lack of cross-reactivity with other hormone receptors is a significant advantage of the K1-70 scFv Fragment. Our experiments have been free from the confounding variables often introduced by non-specific binding.
Effectiveness as an inhibitor
Signal inhibition experiments using the K1-70 scFv Fragment have yielded new insights into TSHR signaling pathways. Its efficacy as an inhibitor makes it an invaluable tool in our research into thyroid-related illnesses.
Q&As
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Is the K1-70 scFv fragment stable under standard laboratory storage conditions?
A: For long-term preservation, the K1-70 scFv fragment is stable at -20°C. It can be kept for a brief period of time at 4°C for up to two weeks without seeing a noticeable decrease in activity.
-
What is the affinity of the Antibody for its target?
A: The thyroid-stimulating hormone receptor (TSHR) is highly selectively bound by the Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment, and its dissociation constant (Kd) is in the nanomolar range.
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Is the Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment effective in inhibiting TSHR signaling?
A: The K1-70 scFv fragment has been shown to effectively inhibit TSHR signaling in vitro, making it a valuable tool for studying TSHR-mediated pathways and potential therapeutic applications.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| PSBW-172 | Human Anti-TSHR Recombinant Antibody (clone M22); scFv Fragment | WB | Human scFv |
| FAMAB-0323CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody (clone 4G11); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0324CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody (clone D2); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0367LY-S(P) | Human Anti-TSHR Recombinant Antibody (clone 5C9); scfv Fragment | Block, ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-353 | Mouse Anti-TSHR Recombinant Antibody Fab Fragment (PFBL-353) | WB, ELISA, FuncS | Mouse Fab |
| PFBL-730 | Human Anti-TSHR Recombinant Antibody Fab Fragment (PFBL-730) | Block | Human Fab |
| FAMAB-0323CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody (clone 4G11); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0328CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody; Fab Fragment (HPAB-0328CQ-F(E)) | ELISA, FC, FuncS | Mouse Fab |
| HPAB-0329CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody; Fab Fragment (HPAB-0329CQ-F(E)) | ELISA, FC, FuncS, Agonist | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-722 | Human Anti-TSHR Recombinant Antibody (clone M22) | WB, IF, FuncS | Human IgG |
| PABL-737 | Human Anti-TSHR Recombinant Antibody (clone K1-70) | Block | Human IgG |
| PABW-172 | Recombinant Human Anti-TSHR Antibody (M22) | WB, ELISA, PK | IgG |
| HPAB-0328CQ | Mouse Anti-TSHR Recombinant Antibody (HPAB-0328CQ) | ELISA, FC, Neut, FuncS | Mouse IgG |
| HPAB-0329CQ | Mouse Anti-TSHR Recombinant Antibody (HPAB-0329CQ) | ELISA, FC, Neut, Agonist, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-189CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-189CQ) | ELISA, BL | Mouse IgG |
| TAB-190CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-190CQ) | ELISA, BL | Mouse IgG |
| TAB-192CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-192CQ) | ELISA, WB, Inhib | Mouse IgG |
| TAB-189CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-189CQ-S(P)) | ELISA, BL | Mouse scFv |
| TAB-190CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-190CQ-S(P)) | ELISA, BL | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-191CQ | Human Anti-TSHR Recombinant Antibody (TAB-191CQ) | ELISA, WB, Inhib | Human IgG |
| TAB-191CQ-S(P) | Human Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-191CQ-S(P)) | ELISA, WB, Inhib | Human scFv |
| TAB-191CQ-F(E) | Human Anti-TSHR Recombinant Antibody; Fab Fragment (TAB-191CQ-F(E)) | ELISA, WB, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0323CQ | Mouse Anti-TSHR Recombinant Antibody (clone 4G11) | ELISA, Inhib | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY264 | AbPlus™ Anti-TSHR Magnetic Beads (49) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC579 | Recombinant Anti-TSHR Vesicular Antibody, EV Displayed (VS-0425-YC579) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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