Human Anti-TSHR Recombinant Antibody scFv Fragment (PSBL-730) (CAT#: PSBL-730)
Recombinant Human Antibody scFv Fragment is specific to TSH receptor (TSHR), expressed in E. coli. The blocking autoantibody scFv fragment binds more N-terminally on the TSHR concave surface than either the stimulating autoantibody M22 or the hormone TSH, and this may reflect its different functional activity.
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Normal Tissue
RNA Expression
Figure 1 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_B_3_5.jpg
Figure 2 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/473/63994_A_6_6.jpg
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000165409-TSHR
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000165409-TSHR
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165409-TSHR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165409-TSHR
Specifications
- Immunogen
- Human thyroid stimulating hormone receptor
- Host Species
- Human
- Type
- Human scFv
- Specificity
- Human TSHR
- Species Reactivity
- Human
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
ScFv Antibody Products
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Mouse Antibody Products
Human Antibody Products
Blocking Antibody Products
IgM Antibody Products
Antibody Magnetic Beads
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-353 | Mouse Anti-TSHR Recombinant Antibody (PABL-353) | WB, ELISA, FuncS | Mouse IgG |
| PABL-722 | Human Anti-TSHR Recombinant Antibody (clone M22) | WB, IF, FuncS | Human IgG |
| PABL-737 | Human Anti-TSHR Recombinant Antibody (clone K1-70) | Block | Human IgG |
| HPAB-0367LY | Human Anti-TSHR Recombinant Antibody (clone 5C9) | Block, ELISA | Human IgG1 |
| HPAB-A1230-YJ | Mouse Anti-TSHR Recombinant Antibody (HPAB-A1230-YJ) | ELISA, FC, Agonist | Mouse IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Better specificity and affinity
The Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment has been a key component in our thyroid illness research. Its excellent specificity and affinity make our assays extremely trustworthy, while the smaller size of the scFv fragment improves tissue penetration for improved imaging.
Non-specific binding.
The lack of cross-reactivity with other hormone receptors is a significant advantage of the K1-70 scFv Fragment. Our experiments have been free from the confounding variables often introduced by non-specific binding.
Effectiveness as an inhibitor
Signal inhibition experiments using the K1-70 scFv Fragment have yielded new insights into TSHR signaling pathways. Its efficacy as an inhibitor makes it an invaluable tool in our research into thyroid-related illnesses.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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