Mouse Anti-TSHR Recombinant Antibody (clone 4G11)

CAT#: FAMAB-0323CQ

Recombinant Mouse Antibody clone 4G11, which is specific to TSHR. The antibody 4G11, selected by the autoantiidiotypic approach following injection of thyrotropin (TSH) into mice, mimic TSH in binding to receptors on thyroid membranes. 4G11 show unequivocal specificity for the TSH receptor.

Published Data Gene Expression
Figure 1 D2 and  4G11 monoclonal antibodies specifically interact with the TSH receptor on FRTL-6 and TSH receptor-transfected FRT cells. Figure 2 Ability of peptides to inhibit the binding of the D2 (A) or  4G11 (B) antibodies to membrane preparations from FRTL-5 rat thyroid cells as a function of peptide concentration. Figure 3 Ability of peptides related to D2 (A) or 4G11 (B) to inhibit the ability of 5 X 10⁻¹⁰ M TSH to increase cAMP levels in rat FRTL-5 thyroid cells.
Figure 1 Thyroid gland Figure 2 Testis Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70) Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4, SCLC-21H, U-266/70)

Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgM
  • Specificity
  • Human TSHR
  • Species Reactivity
  • Human
  • Clone
  • 4G11
  • Applications
  • ELISA, Inhib
  • Related Disease
  • Graves' disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Inhibition.

Target

  • Alternative Names
  • TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I; hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor; isoform 2
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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