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CD40

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CD40 is a costimulatory protein found on antigen-presenting cells that is required for its activation. Binding of CD154 to CD40 on T cells activates antigen presenting cells and induces a variety of downstream effects. Lack of type 3 can cause Hyper-IgM syndrome. The protein receptor encoded by this gene is a member of the TNF receptor superfamily. This receptor has been found to be essential in mediating a wide variety of immune and inflammatory responses including T cell dependent immunoglobulin class switching, memory B cell development and germinal center formation. It has been reported that the AT-hook transcription factor AKNA coordinates the expression of this receptor and its ligand, which may be important for homotypic cell interactions. The expression of CD40 is varied. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells, and macrophages. It can also be expressed by endothelial cells, smooth muscle cells, fibroblasts and epithelial cells. Consistent with its widespread expression on normal cells, CD40 is also expressed on a variety of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myelomas, and some cancers, including nasopharyngeal, bladder, and cervical cancers. , kidney and ovarian cancer. CD40 is also expressed on B-cell precursors in bone marrow, and there is evidence that the CD40-CD154 interaction may play a role in controlling B-cell hematopoiesis. Bleselumab (trade name ASKP1240) is a human monoclonal antibody for preventing organ transplant rejection. The drug was developed by Concord Kirin Pharmaceuticals.

Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Cross-react with mouse CD40
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FC, FuncS
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