Anti-Human CD40 Recombinant Antibody (Selicrelumab) (CAT#: TAB-470CQ)
Recombinant monoclonal antibody to CD40. Selicrelumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.
Specific Inquiry
Figure 1 Assessment of TME by histopathologic and immunohistochemistry of the surgical resection specimen.
Representative images of Mason's trichrome staining from (A) treatment naïve cohort of UPenn patients or (B) patients treated with selicrelumab (Arm I). Red lines indicate the border of tumor regions. (C) Quantification of percent fibrosis in the TME for a set of untreated control PDAC resection samples and samples from Arm I and Arm II, as indicated.
Byrne, K. T., Betts, C. B., Mick, R., Sivagnanam, S., Bajor, D. L., Laheru, D. A., ... & Vonderheide, R. H. (2021). Neoadjuvant selicrelumab, an agonist CD40 antibody, induces changes in the tumor microenvironment in patients with resectable pancreatic cancer. Clinical Cancer Research, 27(16), 4574-4586.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG2, κ
- Specificity
- Human CD40
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- CAS
- 1622140-49-1
- Generic Name
- Selicrelumab
- UNII
- 0O39RGI33V
- Related Disease
- Solid tumors
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The CD40 antibody has been reported in applications of PK.
Pharmacokinetic: Lucatumumab serum levels were collected before dosing, at the end of the infusion, 2 h after the end of the infusion and 24, 48, 96 and 168 h after the start of the first and fourth infusions. Additional time points beyond 168 h were collected after the fourth infusion at 336, 504, 672 and 840 h and every other week thereafter as well as before and after the second and third infusions.
Target
Related Resources
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Selicrelumab"
Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. Selicrelumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.
See other products for "CD40"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-759 | Anti-CD40 Recombinant Antibody (Lucatumumab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG1 - kappa |
| TAB-195LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P)) | ELISA | Human scFv |
| TAB-196LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P)) | ELISA | Human scFv |
| TAB-197LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P)) | ELISA | Human scFv |
| TAB-198LC-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P)) | ELISA | Human scFv |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-470CQ, RRID: AB_3111960)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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