Anti-Human CD40 Recombinant Antibody (Selicrelumab)

CAT#: TAB-470CQ

Recombinant monoclonal antibody to CD40. Selicrelumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

Gene Expression Tested Data
Figure 1 Lymph node Figure 2 Tonsil Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
Figure 1 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in SDS-PAGE Figure 2 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in HPLC Figure 3 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in WB Figure 4 Anti-Human CD40 Recombinant Antibody (Selicrelumab) (TAB-470CQ) in ELISA

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG2, κ
  • Specificity
  • Human CD40
  • Species Reactivity
  • Human
  • Conjugate
  • Unconjugated
  • CAS
  • 1622140-49-1
  • Generic Name
  • Selicrelumab
  • UNII
  • 0O39RGI33V
  • Related Disease
  • Solid tumors

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The CD40 antibody has been reported in applications of PK.
    Pharmacokinetic: Lucatumumab serum levels were collected before dosing, at the end of the infusion, 2 h after the end of the infusion and 24, 48, 96 and 168 h after the start of the first and fourth infusions. Additional time points beyond 168 h were collected after the fourth infusion at 336, 504, 672 and 840 h and every other week thereafter as well as before and after the second and third infusions.

Target

  • Alternative Names
  • p50; Bp50; CDW40; TNFRSF5
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Breast cancer biomarkers at key points during disease progression
Highly Reliable in Cancer Research
Selicrelumab has proven incredibly useful in our studies on solid tumors. Its high specificity and sensitivity to CD40 allow us to effectively monitor and analyze tumor-immune interactions. This antibody has significantly contributed to the reliability and depth of our cancer biomarker research, enabling us to draw insightful conclusions.
Breast cancer biomarkers at key points during disease progression
Excellent for Flow Cytometry
Utilizing Selicrelumab in flow cytometry has been straightforward and effective. Its high affinity and precise targeting capabilities have allowed us to accurately assess CD40 expression, which is key in our research on tumor microenvironments. We appreciate its stability and consistency across experiments.
Breast cancer biomarkers at key points during disease progression
A Robust Tool for Immunoprecipitation
Our lab consistently sees positive outcomes with Selicrelumab in immunoprecipitation applications. Its robustness and purity ensure we can isolate CD40 with minimal background interference, providing clean results necessary for analyzing protein interactions in solid tumors.

Q&As

  1. What research applications is Selicrelumab suitable for?

    A: Selicrelumab is primarily used in applications such as ELISA, immunohistochemistry (IHC), flow cytometry (FC), and immunoprecipitation (IP). These methods help in analyzing the expression of CD40 in various samples and understanding its implications in solid tumors.

  2. What diseases can Selicrelumab help study?

    A: This antibody is particularly useful in studying solid tumors. Its ability to target CD40 makes it a valuable tool in cancer research, providing insights into immune response modulation and tumor progression.

  3. Is this antibody available in a conjugated form?

    A: While the standard offering is unconjugated, there are conjugation options available, such as PE, APC, Biotin, and FITC. These can be selected according to the specific needs of the research being conducted.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-470CQ, RRID: AB_3111960)

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Related Diseases

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Protocol & Troubleshooting

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-470CQ)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. It is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

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