The tenth fibronectin type III domain (10Fn3) that bound Cd40l was isolated from the library using phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1 nM) for Cd40l as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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For Research Use Only. Not For Clinical Use.