10-FnIII scaffold protein anti-Human Cd40l (CAT#: SFN-L034)

The tenth fibronectin type III domain (10Fn3) that bound Cd40l was isolated from the library using phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1 nM) for Cd40l as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Specific Inquiry
  • Size:

  • Conjugation:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Tenascin-3
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2–3 Loops
  • Target
  • Cd40l
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 1 nM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Tenascin-3; 10-FnIII; CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule

Related Resources

  • Related Diseases

Downloads

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