10-FnIII scaffold protein anti-Human Cd40l (CAT#: SFN-L034)
The tenth fibronectin type III domain (10Fn3) that bound Cd40l was isolated from the library using phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1 nM) for Cd40l as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Tenascin-3
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- Cd40l
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 1 nM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Tenascin-3; 10-FnIII; CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule
- Gene ID
- 958
- UniProt ID
- P25942
Related Resources
Asthma
Systemic Lupus Erythematosus
Primary Immunodeficiency
Allograft Rejection
Autoimmune Thyroid Disease
Downloads
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See other products for "CD40"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-262 | Anti-Human CD40 Recombinant Antibody (Teneliximab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 |
| TAB-202LC | Anti-CD40 Recombinant Antibody (TAB-202LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG1 |
| TAB-203LC | Anti-CD40 Recombinant Antibody (TAB-203LC) | ELISA, FC, FuncS | Chimeric (mouse/rhesus) IgG4 |
| TAB-188LC-S(P) | Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220) | SPR, ELISA | Chimeric antibody (mouse/human) |
| TAB-192LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-192LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-759 | Anti-CD40 Recombinant Antibody (Lucatumumab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG1 - kappa |
| TAB-195LC | Human Anti-CD40 Recombinant Antibody (TAB-195LC) | ELISA, Agonist | Human IgG2 |
| TAB-196LC | Human Anti-CD40 Recombinant Antibody (TAB-196LC) | ELISA, Agonist | Human IgG2 |
| TAB-197LC | Human Anti-CD40 Recombinant Antibody (TAB-197LC) | ELISA, Agonist | Human IgG2 |
| TAB-470CQ | Anti-Human CD40 Recombinant Antibody (Selicrelumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G079E | Anti-CD40 immunotoxin G28-5 (scFv)-PE | Cytotoxicity assay, Function study |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-126CL | Human Anti-CD40 Recombinant Antibody (TAB-126CL) | Block, Cyt, FuncS, Inhib | Human IgG |
| TAB-200LC | Human Anti-CD40 Recombinant Antibody (TAB-200LC) | ELISA | Human IgG1, κ |
| TAB-189LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (F4) | SPR, ELISA | Humanized antibody |
| TAB-190LC-F(E) | Anti-Human CD40 Recombinant Antibody Fab Fragment (L3.17) | SPR, ELISA | Humanized antibody |
| TAB-194LC-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (TAB-194LC-F(E)) | ELISA | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-178LC | Mouse Anti-CD40 Recombinant Antibody (TAB-178LC) | FC, ELISA | Mouse IgG |
| TAB-179LC | Mouse Anti-CD40 Recombinant Antibody (TAB-179LC) | FC, ELISA | Mouse IgG |
| TAB-180LC | Mouse Anti-CD40 Recombinant Antibody (TAB-180LC) | FC, ELISA | Mouse IgG |
| TAB-181LC | Mouse Anti-CD40 Recombinant Antibody (TAB-181LC) | FC, ELISA | Mouse IgG |
| TAB-182LC | Mouse Anti-CD40 Recombinant Antibody (TAB-182LC) | FC, ELISA | Mouse IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-362CQ | Human Anti-CD40 Recombinant Antibody (clone 5D12) | Block, ELISA, FC, SPR, IP, IHC | Human IgG4, κ |
| NEUT-363CQ | Mouse Anti-CD40 Recombinant Antibody (clone 5C3) | FC, Block, Activ | Mouse IgG1, κ |
| NEUT-365CQ | Hamster Anti-CD40 Recombinant Antibody (clone HM40-3) | FC, Block, Costim, IHC | Hamster IgM |
| NEUT-366CQ | Rat Anti-CD40 Recombinant Antibody (clone MAB0819) | Block, Activ | Rat IgG2 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-364CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL829) | WB, Neut | Mouse IgG2b, κ |
| NEUT-367CQ | Mouse Anti-CD40 Recombinant Antibody (clone CBL013) | WB, IHC, Neut | Mouse IgG2 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4059 | Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS) | ELISA | Rabbit IgG |
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-105LC | Human Anti-CD40 Recombinant Antibody (MOB-105LC) | FC, FuncS | Human IgG1, κ |
| MOB-106LC | Human Anti-CD40 Recombinant Antibody (MOB-106LC) | FC, FuncS, ELISA | Human IgG2, κ |
| MOB-107LC | Human Anti-CD40 Recombinant Antibody (MOB-107LC) | FC, FuncS, ELISA | Human IgG2, κ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0164-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0164-YC) | FC, Agonist | Human IgG |
| HPAB-0165-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0165-YC) | FC | Human IgG |
| HPAB-0166-YC | Human Anti-CD40 Recombinant Antibody (clone S2C6) | FC, FuncS | Human IgG |
| HPAB-0167-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0167-YC) | ELISA, FC, Neut, Agonist | Human IgG2, κ |
| HPAB-0168-YC | Human Anti-CD40 Recombinant Antibody (HPAB-0168-YC) | ELISA, FC, Neut, FuncS | Human IgG1, κ |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-021CN | Human Anti-CD40 Recombinant Antibody (NS-021CN) | ELISA, IF, Block, FuncS | Human IgG |
| NS-021CN-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E)) | ELISA | Human Fab |
| NS-021CN-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P)) | ELISA | Human scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110LY-S(P) | Mouse Anti-CD40 Recombinant Antibody (clone CBL020); scfv Fragment | ELISA | Mouse scfv |
| PSBC-514 | Human Anti-CD40 Recombinant Antibody (clone Chi Lob 7/4); scFv Fragment | ELISA, FC, WB, Agonist | Mouse scFv |
| HPAB-0498-WJ-S(P) | Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-0498-WJ-S(P)) | ELISA | Human scFv |
| HPAB-1672-FY-F(E) | Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1672-FY-F(E)) | Inhib | Human Fab |
| HPAB-1834-FY-F(E) | Human Anti-CD40 Recombinant Antibody (clone 21.4.1); scFv Fragment | Agonist, Activ | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110LY-F(E) | Mouse Anti-CD40 Recombinant Antibody (clone CBL020); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1662LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1662LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1663LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1663LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1664LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1664LY-F(E)) | ELISA, RIA | Mouse Fab |
| HPAB-1665LY-F(E) | Mouse Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-1665LY-F(E)) | ELISA, RIA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-152 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Dacetuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-262 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Teneliximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-759 | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Lucatumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-470CQ | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Selicrelumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-006ML | Afuco™ Anti-CD40 ADCC Recombinant Antibody (Bleselumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1218WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-1) | ELISA | Llama VHH |
| HPAB-1219WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-2) | ELISA | Llama VHH |
| HPAB-1220WJ | Recombinant Llama Anti-CD40 Single Domain Antibody (CD40-3) | ELISA | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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