Anti-CEA Antibody-Cytokine Fusion Protein, p40-ScFv (T84.66)-p35

Name: Anti-CEA Antibody-Cytokine Fusion Protein, p40-ScFv (T84.66)-p35
SKU: ACFP-SH169
Rating: 5 (1 reviews)

CAT#: ACFP-SH169

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CEA ScFv to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the CEA as well as the biological activity of IL12. The aCEA-(hIL12) fusion protein induced the in vitro proliferation of PHA-PBMC and was able to induce LAK cells to inhibit the in vitro growth of TFK-1 cells (human bile duct carcinoma). This Immunocytokines was designed for treating human bile duct carcinoma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg

Normal Tissue Figure 4 Rectum

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

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Specifications

Target
CEA

Molecule Class
p40-scFv-p35

Species Reactivity
Human

Expression Host
CHO

Clone
T84.66

Related Disease
Human bile duct carcinoma

Cytokine 1
IL12

Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.

Cytokine 1 Species
Human

Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Alternative Names
CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Gene ID
1048

UniProt ID
A0A024R0K5

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Datasheet

Datasheet - ACFP-SH169.pdf

MSDS

MSDS - ACFP-SH169.pdf

COA

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