Afuco™ Anti-Human CSF1 ADCC Recombinant Antibody (PD-0360324), ADCC Enhanced (CAT#: AFC-177CL)
Anti-CSF1 ADCC Enhanced Antibody (PD-0360324) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a novel neutralizing human monoclonal antibody against monocyte/ macrophage colony stimulating factor (M-CSF). It exhibited a nonlinear PK profile associated with rapid suppression of PD markers and was generally well tolerated. The safety and efficacy profile will be investigated further in a multi-dose study in patients with rheumatoid arthritis.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
Figure 2 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Rheumatoid Arthritis; Sarcoidosis; Systemic lupus erythematosus
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Target
- Alternative Names
- CSF1; colony stimulating factor 1 (macrophage); MCSF; CSF-1; macrophage colony-stimulating factor 1; lanimostim
- Gene ID
- 1435
- UniProt ID
- A0A024R0A1
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Humanized Antibody Products
Fab Antibody Products
ADCC Enhanced Antibody Products
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-245 | Recombinant Human Anti-human CSF1 Antibody | ELISA, WB, FuncS | IgG |
| HPAB-0110-WJ | Human Anti-CSF1 Recombinant Antibody (HPAB-0110-WJ) | ELISA, FC, WB | Human IgG1 |
| HPAB-0748-WJ | Human Anti-CSF1 Recombinant Antibody (clone 88) | ELISA, WB, FC | Human IgG |
| HPAB-0749-WJ | Human Anti-CSF1 Recombinant Antibody (clone 100) | ELISA, WB, FC | Human IgG |
| HPAB-0750-WJ | Human Anti-CSF1 Recombinant Antibody (clone 3.8.3) | ELISA, WB, FC | Human IgG |
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