Afuco™ Anti-Human CSF1 ADCC Recombinant Antibody (PD-0360324), ADCC Enhanced (CAT#: AFC-177CL)
Anti-CSF1 ADCC Enhanced Antibody (PD-0360324) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a novel neutralizing human monoclonal antibody against monocyte/ macrophage colony stimulating factor (M-CSF). It exhibited a nonlinear PK profile associated with rapid suppression of PD markers and was generally well tolerated. The safety and efficacy profile will be investigated further in a multi-dose study in patients with rheumatoid arthritis.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
Figure 2 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Rheumatoid Arthritis; Sarcoidosis; Systemic lupus erythematosus
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Target
- Alternative Names
- CSF1; colony stimulating factor 1 (macrophage); MCSF; CSF-1; macrophage colony-stimulating factor 1; lanimostim
- Gene ID
- 1435
- UniProt ID
- A0A024R0A1
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
Humanized Antibody Products
ADCC Enhanced Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-245-F(E) | Recombinant Anti-human CSF1 Antibody Fab Fragment | WB, RIA, FuncS | Fab |
| HPAB-0150CQ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0150CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-0151CQ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0151CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-0110-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0110-WJ-F(E)) | ELISA, FC, WB | Human Fab |
| HPAB-0748-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody (clone 88); Fab Fragment | ELISA, WB, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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