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FGFR2

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The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Species Reactivity:
Human
Type:
Antibody
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
FGFR2
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
FGFR2
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Species Reactivity:
Human
Application:
ELISA, FC
Species Reactivity:
Human, Mouse, Cynomolgus monkey, Chimpanzee
Application:
ELISA, FC, BL
Species Reactivity:
Human
Type:
Humanized Antibody
Application:
ELISA, FC, BL
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