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    Anti-FGFR2 Products

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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs offers a diverse range of highly effective anti-FGFR2 recombinant antibodies, expertly developed for application in a number of immunological examinations. These antibodies are engineered with extreme precision and specificity, empowering researchers to investigate the role of FGFR2 in numerous biological mechanisms with confidence.

    FGFR2: A Prospective Therapeutic Target for Cancer Therapy

    FGFR2 (Fibroblast Growth Factor Receptor 2) is a receptor tyrosine kinase that plays a crucial role in various biological processes, including cell proliferation, differentiation, and migration. FGFR2 is abnormally expressed in many cancers, including bile duct cancer, gastric cancer, breast cancer, etc. Overexpression, mutations, or excessive activation by its ligands frequently result in uncontrolled cell growth and proliferation, which fuels cancer formation and progression. As a result, FGFR2 has emerged as a prospective therapeutic target.

    Alternative Names

    Fibroblast growth factor receptor 2; FGF receptor; bacteria-expressed kinase; BEK fibroblast growth factor receptor; BEK protein tyrosine kinase; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14; tyrosylprotein kinase; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; K-SAM; KGFR; TK14; TK25.

    Background

    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where the amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
    Protein class

    Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Group enriched (Oligodendrocytes, Astrocytes, Cholangiocytes)

    Immune cell specificity

    Group enriched (basophil, eosinophil)

    Cell line specificity

    Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)

    Interaction

    Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, FGF10, FGF17, FGF18 and FGF22 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Isoform 1 has high affinity for FGF1 and FGF2, but low affinity for FGF7. Isoform 3 has high affinity for FGF1 and FGF7, and has much higher affinity for FGF7 than isoform 1 (in vitro). Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19 and FGF21. Interacts with PLCG1, GRB2 and PAK4. Interacts with FLRT2 (By similarity).

    Molecular function

    Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    More Types Infomation

    Anti-FGFR2 Recombinant Antibody Products

    Creative Biolabs provides a diverse range of recombinant antibodies targeting FGFR2, each professionally engineered for reliable identification and neutralization. Available in a variety of forms, these antibodies exhibit remarkable specificity and affinity, making them wonderful for a wide range of applications. Creative Biolabs' anti-FGFR2 antibodies provide crucial aids in furthering understanding in immunology, cancer, and other domains.

    Table 1. Featured anti-FGFR2 recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    TAB-055WM Anti-Human FGFR2 Recombinant Antibody (GP369/4B9) Human Mouse FC
    TAB-284CL Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) Human Human IF, WB
    HPAB-0674-WJ Human Anti-FGFR2 Recombinant Antibody (clone M047-D08) Human Human IgG ELISA, FC
    NS-027CN Human Anti-FGFR2 Recombinant Antibody (clone M048-D01) Human, Mouse Human IgG1 ELISA, WB, FC
    HPAB-AP350-YC Rat Anti-FGFR2 Recombinant Antibody (HPAB-AP350-YC) Human Rat IgG ELISA, FC, Neut, ADCC, FuncS

    Creative Quality Control

    Creative Biolabs is a top source of precise anti-FGFR2 recombinant antibodies designed for cutting-edge research. We provide antibodies with outstanding properties by combining sophisticated biotechnology processes with restricted quality assurance. Our expert scientists are dedicated to providing dependable solutions that support your research pursuits, ranging from fundamental biology to drug development.

    Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-FGFR2 antibody
    (Cat# HPAB-0674-WJ, Creative Biolabs).

    Fig.2 HPLC analysis. (Creative Biolabs Original)Fig.2 HPLC analysis of anti-FGFR2 antibody
    (Cat# HPAB-0674-WJ, Creative Biolabs).

    Fig.3 WB analysis. (Creative Biolabs Original)Fig.3 WB analysis of anti-FGFR2 antibody
    (Cat# HPAB-0674-WJ, Creative Biolabs).

    Fig.4 ELISA analysis. (Creative Biolabs Original)Fig.4 ELISA analysis of anti-FGFR2 antibody
    (Cat# HPAB-0674-WJ, Creative Biolabs).

    Fig.5 Dot Blot analysis. (Creative Biolabs Original)Fig.5 Dot Blot analysis of anti-FGFR2 antibody
    (Cat# HPAB-0674-WJ, Creative Biolabs).

    Fig.6 ELISA analysis. (Creative Biolabs Original)Fig.6 ELISA analysis of anti-FGFR2 antibody
    (Cat# NS-027CN, Creative Biolabs).

    Customer Reviews

    Excellent
    Yu***e
    Rat Anti-FGFR2 Recombinant Antibody (HPAB-AP350-YC) (HPAB-AP350-YC)
    Creative Biolabs' anti-FGFR2 antibodies have been extremely useful in our study on FGFR2-mediated signaling networks. These reagents' extraordinary specificity and affinity allowed us to accurately target and study FGFR2 expression and activity in a variety of biological situations. These antibodies' constant performance and dependability have helped further our understanding of FGFR2's function in cancer etiology.
    7/May2022
    Excellent
    Pa***i
    Rabbit Anti-FGFR2 Polyclonal Antibody (MRO-1862-CN) (MRO-1862-CN)
    We've got outstanding results using Creative Biolabs' anti-FGFR2 antibodies in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. These reagents' constant performance and great sensitivity enabled us to collect trustworthy and repeatable data. These antibodies' adaptability has been vital for our study, allowing us to explore FGFR2 expression and function in numerous experimental paradigms.
    2/Nov/2022
    Excellent
    Ma***n
    Human Anti-FGFR2 Recombinant Antibody (HPAB-AP349-YC) (HPAB-AP349-YC)
    Apart from the great quality of their products, Creative Biolabs has also offered exceptional technical assistance and customer service. Their team of professionals has been on hand to respond to our inquiries, offer advice, and help with problems. The prompt responses and personalized attention have proven critical to the success of our research projects.
    21/Oct/2023

    Anti-FGFR2 Recombinant Antibody Production

    Creative Biolabs utilizes advanced recombinant antibody production techniques specifically designed for generating anti-FGFR2 antibodies. Our innovative genetic engineering approaches facilitate the efficient and high-quality synthesis of antibodies, guaranteeing a consistent and dependable supply for all your research needs.

    Featured Anti-FGFR2 Recombinant Antibody Production Platforms Fig.7 Milligram-scale. (Creative Biolabs Original)
    Fig.7 Milligram-scale anti-FGFR2 recombinant antibody production.

    Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-FGFR2 recombinant antibody production.

    Anti-FGFR2 Recombinant Antibody Modalities

    Creative Biolabs offers a diverse range of premium anti-FGFR2 recombinant antibodies tailored to meet the specific needs of researchers globally. Our products are available in various formats, ensuring adaptability and effectiveness for a wide array of scientific applications.

    Fig.9 FGFR2 antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-FGFR2 recombinant antibody production and modalities.

    FGFR2-Targeted Drug Information

    Public Drug Information Targeting FGFR2

    Table 2. Public drug targeting FGFR2.

    Company Research Phase Classification Condition
    DePuy Orthopaedics
    Kaken
    Nobelpharma
    Olympus
    Scios (Originator)
    Sunstar     		Launched - 2001 Basic Fibroblast Growth Factor (bFGF; FGF-2)
    Polypeptides, from 41 AA
    Recombinant proteins     		Coronary artery disease
    Dental Diseases
    Fracture
    Inflammatory bowel disease
    Periodontitis
    Stroke, ischemic
    Tympanic membrane perforation
    Ulcer foot, diabetic
    Ulcer, skin
    Vascular disease, peripheral
    Essex Bio-Technology (Originator) Launched - 1998 Polypeptides, from 41 AA
    Recombinant proteins     		Corneal ulcer
    Dry eye
    Lesion, skin
    Amgen (Originator)
    Five Prime Therapeutics (Amgen)
    Zai Lab
    Zai Lab     		Phase III Cancer Immunotherapy
    Humanized Monoclonal Antibodies     		Cancer, bladder (urothelial carcinoma, transitional cell)
    Cancer, gastroesophageal junction
    Cancer, lung (non-small cell) (NSCLC) (squamous cell carcinoma)
    Cancer, stomach
    Akero Therapeutics
    Amgen (Originator)     		Phase III Basic Fibroblast Growth Factor (bFGF; FGF-2)
    Fc Fusion Proteins
    Polypeptides, from 41 AA     		Cirrhosis
    Diabetes type 2
    Non-alcoholic steatohepatitis (NASH)
    Amgen (Originator) Phase III Basic Fibroblast Growth Factor (bFGF; FGF-2)
    Peptides
    Recombinant proteins     		Lesion, skin
    Kaken
    Novartis Vaccines and Diagnostics (Originator)     		Phase II Basic Fibroblast Growth Factor (bFGF; FGF-2)
    Polypeptides, from 41 AA
    Recombinant proteins     		Coronary artery disease
    Osteoporosis
    Vascular disease, peripheral
    Daiichi Sankyo (Originator) Phase I Antibodies
    Cancer Immunotherapy     		Cancer, solid tumor
    Bayer (Originator) Phase I Cancer Immunotherapy
    Monoclonal Antibodies     		Cancer, solid tumor
    Inst of Genetics & Developmental Biology (Originator) Clinical Basic Fibroblast Growth Factor (bFGF; FGF-2)
    Fusion Proteins
    Polypeptides, from 41 AA     		Infertility, female
    Universita degli Studi "La Sapienza" (Originator) Preclinical Nuclear Imaging Agents
    Polypeptides, from 41 AA
    Radionuclide Therapy
    Radiopharmaceuticals
    Recombinant proteins
    Technetium Complexes     		Cancer, solid tumor
    Genor Biopharma (Originator) Preclinical Cancer Immunotherapy
    Murine Monoclonal Antibodies     		Cancer, gastrointestinal

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    Creative Biolabs focuses on producing high-quality anti-FGFR2 recombinant antibodies for rigorous scientific study. Our antibodies are precisely developed to achieve excellent accuracy and specificity, making them ideal for a wide range of laboratory applications. Contact us to learn more about your specific needs and how our anti-FGFR2 antibodies will help you achieve your research objectives.

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