Human Anti-FGFR2 (clone 4B9) scFv-Fc Chimera (CAT#: VS-0325-FY132)

• Immunogen
• A 1: 1 mixture of human FGFR2 IgD2-IgD3 (Illb) and human FGFR2 IgD2-IgD3 (IIIc) fused with a human Fc moiety at their C-termini.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human FGFR2

• Species Reactivity
• Human

• Clone
• 4B9

• Applications
• Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Fibroblast Growth Factor Receptor 2; Keratinocyte Growth Factor Receptor; Bacteria-Expressed Kinase; EC 2.7.10.1; K-SAM; KGFR; BEK; Protein Tyrosine Kinase, Receptor Like 14; BEK Fibroblast Growth Factor Receptor; Craniofacial Dysostosis 1; Jackson-Weiss Syndrome; Pfeiffer Syndrome; Crouzon Syndrome; CD332 Antigen

• Gene ID
• 2263

• UniProt ID
• P21802

• Long Name
• Fibroblast Growth Factor Receptor 2

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

• Cellular Localization
• Cell membrane; Golgi apparatus; Cytoplasmic vesicle

• Post Translation Modifications
• Autophosphorylated.
  Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on several tyrosine residues.
  Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
  Phosphorylation at Tyr-769 is essential for interaction with PLCG1.
  N-glycosylated in the endoplasmic reticulum.
  The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.
  Ubiquitinated.
  FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation.
  Subject to degradation both in lysosomes and by the proteasome.
  Glycosylation at Asn83, Asn228, Asn123, Asn241, Asn265, Asn297, Asn318, and Asn331
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect FGFR2_HUMAN (1997)
  Glycosylation from GlyGen 10 sites, 6 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• XP_006717771.1; XP_006717773.1; XP_016871409.1; XP_016871410.1; XP_016871413.1

• Function
• FGFR2 (Fibroblast Growth Factor Receptor 2) is a tyrosine kinase receptor involved in cell proliferation, differentiation, and angiogenesis. It plays a critical role in skeletal development and tissue repair, and its mutations are associated with various developmental disorders and cancers.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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