Afuco™ Anti-Human FGFR2 ADCC Recombinant Antibody (BAY 1179470), ADCC Enhanced (CAT#: AFC-271CL)
Anti-FGFR2 ADCC Enhanced Antibody (BAY 1179470) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
Figure 2 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
Figure 3 IHC staining of human skin
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
(Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
Specifications
- Host Species
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FGFR2"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Intrabody Products
Rat Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
Neuroscience Antibody Products
ScFv Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1370z | Mouse Anti-FGFR2 Recombinant Antibody (clone 5F10) | ELISA, IHC, WB | Mouse IgG2b, κ |
| HPAB-0144-YC | Human Anti-FGFR2 Recombinant Antibody (clone Hu4B9-65) | FuncS | Humanized IgG1, κ |
| HPAB-0146-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-0146-YC) | ELISA, FC, Neut | Chimeric (rat/human) IgG |
| HPAB-0147-YC | Human Anti-FGFR2 Recombinant Antibody (HPAB-0147-YC) | ELISA, FC, Neut | Humanized IgG |
| MRO-1861-CN | Rabbit Anti-FGFR2 Polyclonal Antibody (MRO-1861-CN) | WB, FC | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Excellent Specificity
This antibody provides exceptional specificity for FGFR2. I used it in Western Blot and obtained clean, distinct bands without any background noise. Highly recommend for targeted studies.
Impressive ADCC Activity
The ADCC enhancement is real and impactful. In our cell cytotoxicity assays, this antibody showed significantly improved efficacy compared to others. A great tool for functional studies.
Highly Specific
We were concerned about cross-reactivity, but this antibody proved to be very specific to FGFR2. It didn't pick up any other FGFR family members. Perfect for targeted research.
Popular products with customers
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IF, FuncS
Application: ELISA, FC, WB, Block
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Neut
Application: ELISA, Cyt, PP, Inhib
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
