Afuco™ Anti-Human FGFR2 ADCC Recombinant Antibody (BAY 1179470), ADCC Enhanced
CAT#: AFC-271CL
Anti-FGFR2 ADCC Enhanced Antibody (BAY 1179470) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human skin
Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
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Specifications
- Host Species
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
REVIEWS AND Q&AS
CITATIONS
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Customer Review
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Excellent Specificity
This antibody provides exceptional specificity for FGFR2. I used it in Western Blot and obtained clean, distinct bands without any background noise. Highly recommend for targeted studies.
Impressive ADCC Activity
The ADCC enhancement is real and impactful. In our cell cytotoxicity assays, this antibody showed significantly improved efficacy compared to others. A great tool for functional studies.
Highly Specific
We were concerned about cross-reactivity, but this antibody proved to be very specific to FGFR2. It didn't pick up any other FGFR family members. Perfect for targeted research.
Q&As
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What is the specific target of the Afuco™ Anti-Human FGFR2 ADCC Recombinant Antibody?
A: The antibody specifically targets the Fibroblast Growth Factor Receptor 2 (FGFR2), which plays a crucial role in developmental processes and tissue repair mechanisms.
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What kind of modifications have been made to enhance ADCC in this antibody?
A: The antibody has been glyco-engineered to enhance its ability to recruit effector cells, thereby increasing its Antibody-Dependent Cellular Cytotoxicity (ADCC) activity.
-
Why is the antibody labeled as "ADCC Enhanced?
A: It has been modified to improve its interactions with Fc receptors on immune cells, thereby boosting its ability to mediate cell death through ADCC mechanisms.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| TAB-284CL | Anti-Human FGFR2 Recombinant Antibody (BAY 1179470) | IF, WB | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-057WM | Human Anti-FGFR2 Recombinant Antibody (TAB-057WM) | ELISA, FC, Block | Human IgG1 |
| TAB-057WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-057WM-S(P)) | ELISA, FC, Block | Human scFv |
| TAB-057WM-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-057WM-F(E)) | ELISA, FC, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-060WM | Anti-Human FGFR2 Recombinant Antibody (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-060WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-061WM-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-061WM-S(P)) | Neut, WB, ELISA | Human scFv |
| TAB-060WM-F(E) | Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-huMab-08) | ELISA, WB, FC | Human Antibody |
| TAB-061WM-F(E) | Human Anti-FGFR2 Recombinant Antibody; Fab Fragment (TAB-061WM-F(E)) | Neut, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
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| TAB-055WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (GP369/4B9) | ELISA, FC | |
| TAB-056WM-S(P) | Mouse Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-056WM-S(P)) | ELISA, FC, Block | Mouse scFv |
| TAB-058WM-S(P) | Rat Anti-FGFR2 Recombinant Antibody; scFv Fragment (TAB-058WM-S(P)) | ELISA, FC, Neut, Inhib | Rat scFv |
| TAB-059WM-S(P) | Anti-Human FGFR2 Recombinant Antibody scFv Fragment (Atto-MuMab-01) | ELISA, WB, FC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0737CT | Recombinant Mouse anti-Human FGFR2 Monoclonal antibody (EML2262) | ICC, IF, IHC-P, WB | |
| HPAB-0020-FY | Mouse Anti-FGFR2 Recombinant Antibody (HPAB-0020-FY) | ELISA | Mouse IgG2b |
| MRO-0580-CN | Mouse Anti-FGFR2 Recombinant Antibody (clone 1-F1-E7) | WB, IF, FC | Mouse IgG1 |
| MRO-0581-CN | Mouse Anti-FGFR2 Recombinant Antibody (clone A5-E10-G7) | WB, IF, IHC | Mouse IgG1 |
| HPAB-0674-WJ | Human Anti-FGFR2 Recombinant Antibody (clone M047-D08) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-828CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL511) | WB, Neut | Mouse IgG1 |
| NEUT-829CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL512) | WB, FC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-830CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL513) | FC, IHC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-831CQ | Mouse Anti-FGFR2 Recombinant Antibody (NEUT-831CQ) | IHC, Neut, WB | Mouse IgG1 |
| NEUT-832CQ | Mouse Anti-FGFR2 Recombinant Antibody (clone CBL060) | Neut, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1298 | Hi-Affi™ Rabbit Anti-FGFR2 Recombinant Antibody (clone DS1298AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0144-YC-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone Hu4B9-65); scFv Fragment | FuncS | Humanized scFv |
| HPAB-0146-YC-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0146-YC-S(P)) | ELISA, FC, Neut | Human scFv |
| HPAB-0147-YC-S(P) | Human Anti-FGFR2 Recombinant Antibody; scFv Fragment (HPAB-0147-YC-S(P)) | ELISA, FC, Neut | Humanized scFv |
| HPAB-0791-FY-F(E) | Mouse Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-0791-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0361-YJ-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone CBF55YJ); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-027CN | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01) | ELISA, WB, FC | Human IgG1 |
| NS-027CN-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); Fab Fragment | ELISA, WB, FC | Human Fab |
| NS-027CN-S(P) | Human Anti-FGFR2 Recombinant Antibody (clone M048-D01); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020-FY-F(E) | Mouse Anti-FGFR2 Recombinant Antibody; Fab Fragment (HPAB-0020-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0674-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M047-D08); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0675-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M017-B02); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0676-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M021-H02); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0677-WJ-F(E) | Human Anti-FGFR2 Recombinant Antibody (clone M054-D03); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY132 | Human Anti-FGFR2 (clone 4B9) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC624 | Recombinant Anti-FGFR2 Vesicular Antibody, EV Displayed (VS-0425-YC624) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2540 | Anti-FGFR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2541 | Anti-Mouse FGFR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2542 | Anti-Rat FGFR2 Immunohistochemistry Kit | IHC |
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