Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-MuMab-01) (CAT#: TAB-059WM-F(E))
Atto-MuMab-01 is a human IgG1 isotype and can elicit strong immune responses of antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cell lysis. And Atto-MuMab-01 can be a potentially therapeutic agent in prostate cancer.
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Figure 1 depicts exemplary Atto-HuMab-01 properties.
Atto-HuMab-01 binding activity to soluble receptor FGFR2-IIIc Loop-III domain (mFc-128aa); negative control=Human IgG.
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Figure 2 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to a soluble receptor with calculated affinity constant 0.04 nM (0.01 nM-0.1 nM).
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Figure 3 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to cell receptor FGFR2-IIIc on stable CHO-IIIc cell with a calculated affinity constant 0.7 nM.
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Figure 4 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to with varying affinity to a subset of FGF receptors. Atto-HuMab-01 (biotinylated) binds to FGFR2-IIIc with similar affinity as previously determined (affinity ˜0.2 nM). Atto-HuMab-01 binds to FGFR3-IIIc, FGFR4 with lower affinity.
Specifications
- Immunogen
- FGFR2: isoform FGFR2-IIIc
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- Atto-MuMab-01
- Applications
- ELISA, WB, FC
- Related Disease
- Prostate Cancer
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B026(A) | Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B026(G) | Recombinant Anti-human FGFR2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B026(T) | Recombinant Anti-human FGFR2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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