Anti-Human FGFR2 Recombinant Antibody Fab Fragment (Atto-MuMab-01) (CAT#: TAB-059WM-F(E))
Atto-MuMab-01 is a human IgG1 isotype and can elicit strong immune responses of antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cell lysis. And Atto-MuMab-01 can be a potentially therapeutic agent in prostate cancer.
Specific Inquiry
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Figure 1 depicts exemplary Atto-HuMab-01 properties.
Atto-HuMab-01 binding activity to soluble receptor FGFR2-IIIc Loop-III domain (mFc-128aa); negative control=Human IgG.
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Figure 2 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to a soluble receptor with calculated affinity constant 0.04 nM (0.01 nM-0.1 nM).
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Figure 3 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to cell receptor FGFR2-IIIc on stable CHO-IIIc cell with a calculated affinity constant 0.7 nM.
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Figure 4 depicts exemplary Atto-HuMab-01 affinity determination.
Atto-HuMab-01 binds to with varying affinity to a subset of FGF receptors. Atto-HuMab-01 (biotinylated) binds to FGFR2-IIIc with similar affinity as previously determined (affinity ˜0.2 nM). Atto-HuMab-01 binds to FGFR3-IIIc, FGFR4 with lower affinity.
Specifications
- Immunogen
- FGFR2: isoform FGFR2-IIIc
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- Atto-MuMab-01
- Applications
- ELISA, WB, FC
- Related Disease
- Prostate Cancer
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| IAB-B026(A) | Recombinant Anti-human FGFR2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
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| IAB-B026(T) | Recombinant Anti-human FGFR2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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