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S100A4

Engineered Antibody
Enables calcium ion binding activity and identical protein binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in neuron projection. Predicted to be active in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Orthologous to human S100A4 (S100 calcium binding protein A4).
S100A4
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Langerhans cells, monocytes, Macrophages, Kupffer cells, NK-cells, T-cells, Skeletal myocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A549, ASC diff, BJ hTERT+, fHDF/TERT166, RPMI-8226)

Interaction

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (PubMed:11836260). Interacts with PGLYRP1; this complex acts as a chemoattractant that promotes lymphocyte movement (PubMed:30713770, PubMed:26654597). Interacts with MYH9; this interaction increases cell motility (PubMed:16707441). Interacts with Annexin 2/ANXA2 (PubMed:28669632). Interacts with TP53; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with CCR5 (PubMed:30713770). Interacts with FCGR3A; this interaction inhibits PKC-dependent phosphorylation of FCGR3A.

More Types Infomation

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