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10-FnIII anti-Kdr (SFN-L030)

The tenth fibronectin type III domain (10Fn3) that bound VEGFR2 was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=0.59 nM) for VEGFR2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
10-FnIII
Origin
Fibronectin
Core Structure
β-sandwich of 7 β-strands
Variable Regions
2–3 loops
Target
VEGFR2
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
0.59 nM
Applications
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
Alternative Names
Fibronectin; 10-FnIII; FLK1; CD309; VEGFR; VEGFR2
Entrez Gene ID
16542
UniProt ID
P35968

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Rabbit Anti-KDR Antibody Fab Fragment (40)    ( HPAB-0099-YC-F(E) )
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Anti-Human KDR Therapeutic Antibody Fab Fragment (VK-B8)    ( TAB-325CQ-F(E) )
>> MORE
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