Anti-KDR Antibody Prodrug, Protease Activated (VS-1025-YC53)

Name: Anti-KDR Antibody Prodrug, Protease Activated (VS-1025-YC53)
SKU: VS-1025-YC53
Rating: 5 (1 reviews)

CAT#: VS-1025-YC53

The Anti-KDR Antibody Prodrug, Protease Activated (VS-1025-YC53) is an antibody prodrug comprised of a recombinant rabbit antibody targeting human KDR, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to KDR protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to KDR effectively. KDR (Kinase insert Domain Receptor), also known as VEGFR2, is the primary receptor for VEGF and the most important mediator of angiogenesis (new blood vessel formation) in tumors. Upon activation by VEGF, KDR signaling drives the proliferation and migration of endothelial cells, forming the blood supply necessary for a tumor to grow beyond a tiny mass. Therapies targeting KDR are a major strategy to starve tumors.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

Normal Tissue Figure 2 Placenta

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR

❮

❯

Specifications

Host Animal
Rabbit

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human KDR

Target
KDR

Species Reactivity
Human, Mouse

Isotype
IgG

Affinity Constant
The IC₅₀ value of this antibody is 4.56 nM.

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.

Alternative Names
FLK1; CD309; VEGFR; VEGFR2

Gene ID
3791

UniProt ID
P35968

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Datasheet

Datasheet - VS-1025-YC53.pdf

MSDS

MSDS - VS-1025-YC53.pdf

COA

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