Human Anti-KDR Recombinant Antibody (TAB-0298CL)
CAT#: TAB-0298CL
This product is a recombinant human antibody that recognizes human KDR (VEGFR-2). In cells and in vivo, TAB-0298CL showed an excellent ability to neutralize VEGFR not only in human but also in mouse and rat.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg
Normal Tissue
Figure 2 Placenta
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human VEGFR
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, FC, ELISA, Inhib, Neut, FuncS
- Related Disease
- Colon Cancer, Lung Cancer,
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- See the COA
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot revealed that TAB-0298CL had inhibitory effect on the phosphorylation of ERK in primary cultured HUVEC cells. Flow Cytometry revealed that TAB-0298CL was strongly bound to endogenous human KDR, which was expressed on the surface of living HUVEC cells. The KDR affinity of the antibody was analyzed in ELISA. After adding the TAB-0298CL, the proliferation of the HUVEC cells treated with VEGF was reduced in an antibody concentration-dependent manner. TAB-0298CL had inhibitory effect on the phosphorylation of KDR and the migration of HUVEC cells induced by VEGF. TAB-0298CL had an angiogenesis inhibitory effect in vivo (rat), and anti-cancer effect in cancer xenograft animal models.
Target
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase);
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
- Long Name
- Kinase insert domain receptor
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| TAB-330CQ | Mouse Anti-KDR Recombinant Antibody (TAB-330CQ) | Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-204 | Human Anti-KDR Recombinant Antibody (clone mAb6.64); Fab Fragment | Neut, Block | Chimeric (mouse/human) Fab |
| HPAB-0246-WJ-F(E) | Human Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0246-WJ-F(E)) | ELISA, IF, FC | Human Fab |
| HPAB-N0154-YC-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-N0154-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-1279-FY-S(P) | Mouse Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-1279-FY-S(P)) | ELISA, FC, Inhib | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-N0154-YC | Mouse Anti-KDR Recombinant Antibody (HPAB-N0154-YC) | ELISA, Inhib | Mouse IgG |
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| HPAB-0502-YJ | Human Anti-KDR Recombinant Antibody (clone 1) | ELISA, Inhib | Human IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0624MZ | Chicken Anti-VEGFR-2 Polyclonal IgY | IHC, WB | Chicken antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1619CQ | Recombinant Mouse Anti-KDR Antibody (23B31) | WB, IP, FC, Neut | |
| NEUT-1620CQ | Recombinant Rat Anti-Kdr Antibody (CBL840) | ELISA(Cap), Neut | IgG2a |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0567-WJ-S(P) | Human Anti-KDR Recombinant Antibody; scFv Fragment (HPAB-0567-WJ-S(P)) | ELISA, FC, WB | Human scFv |
| HPAB-1279-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1279-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
| HPAB-1280-FY-F(E) | Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1280-FY-F(E)) | ELISA, FC, Inhib | Mouse Fab |
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| CAT | Product Name | Application | Type |
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|---|---|---|---|
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