Anti-CD2 Intrabody [Tat] (IAB-B074(T))
Recombinant anti-CD2 intrabody in fusion with HIV Tat works within cells that topretransfected with the relevant cell surface antigen CD2, expressed in E. coli cells.
Specifications
- Immunogen
- human CD2 molecule
- Host
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Target
- Alternative Names
- CD2; CD2 molecule; T11; SRBC; LFA-2; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor
- Entrez Gene ID
- 914
- UniProt ID
- P06729
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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