Rat Anti-CD2 Recombinant Antibody (clone RM2-5)
CAT#: NEUT-301CQ
This antibody is a rat monoclonal antibody that binds specifically to mouse CD2, and it can neutralize the bioactivity of mouse CD2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
❮
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Specifications
- Immunogen
- BALB/c mouse thymocytes
- Host Species
- Rat
- Type
- Rat IgG2b, λ
- Specificity
- Recognizes Mouse CD2
- Species Reactivity
- Mouse
- Clone
- RM2-5
- Applications
- FC, IP, Block, Costim
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Reliable Stability
RM2-5 has shown remarkable stability at -20°C across multiple experiments, maintaining its functionality and ensuring consistent data integrity in our studies.
Flow Cytometry Compatible
Using RM2-5 in flow cytometry provided clear and specific results for analyzing CD2 expression and T-cell activation markers, enhancing our data quality.
High Specificity
RM2-5 demonstrated high specificity in our assays, showing no off-target binding. This reliability ensured that our research findings were accurate and dependable.
Q&As
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Is RM2-5 appropriate for rat models used in in vivo research?
A: Answer: Yes, RM2-5 can be used in vivo to study T-cell responses within rat models, allowing for the assessment of CD2-mediated T-cell activation in a physiological context.
-
Can complicated immune responses be studied using RM2-5 in combination with other antibodies?
A: Yes, RM2-5 can be combined with antibodies targeting other markers to study complex immune responses. This approach provides a comprehensive analysis of immune interactions and signaling networks.
-
Is it possible to use RM2-5 in studies on cancer immunotherapy?
A: Yes, RM2-5 can be used to evaluate the impact of CD2-mediated T-cell activation on anti-tumor responses, contributing to the development of novel cancer immunotherapy strategies.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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