Afuco™ Anti-CD2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-104)
CAT#: AFC-TAB-104
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD2. It is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to nucleoplasm, plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/2036_G3_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_8_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3883/11413_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HDLM-2, JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116824-CD2
❮
❯
Specifications
- Immunogen
- Human CD2 recombinant protein
- Host Species
- Human
- Derivation
- Humanized (from rat)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF
- Conjugate
- Unconjugated
- Generic Name
- Siplizumab
- Related Disease
- Psoriasis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Siplizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Siplizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Siplizumab"
DrugMonitor™ Anti-Siplizumab Antibody (VS-1224-YC1094)Siplizumab, a humanized anti-CD2 monoclonal antibody, has been used for conditioning in hematopoietic cell transplantation and tolerance induction with combined kidney-bone marrow transplantation. The DrugMonitor™ Anti-Siplizumab Antibody (VS-1224-YC1094) is an anti-drug antibody (ADA) against Siplizumab. This drug-based antibody is raised in mice immunized with the Siplizumab. The anti-Siplizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Siplizumab in samples.
See other products for "CD2"
Select a product category from the dropdown menu below to view related products.
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|---|---|---|---|
| IAB-B074(A) | Recombinant Anti-human CD2 Intrabody [(D-Arg)9] | PCA, WB, FuncS | scFv-(D-Arg)9 |
| IAB-B074(G) | Recombinant Anti-human CD2 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
| IAB-B074(T) | Recombinant Anti-human CD2 Intrabody [Tat] | ELISA, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-104 | Anti-Human CD2 Recombinant Antibody (TAB-104) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-110CL | Anti-Human CD2 Recombinant Antibody (BTI-322) | FuncS | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0270MZ | Mouse Anti-CD2 Recombinant Antibody (clone BB76) | IHC | Mouse IgG1 |
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| ZG-0903F | Mouse Anti-CD2 Recombinant Antibody (clone T6.3) | FC | Mouse IgG2a |
| VS-0723-WK136 | Human Anti-CD2 Recombinant Antibody (VS-0723-WK136) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-295CQ | Mouse Anti-CD2 Recombinant Antibody (clone CBL975) | WB, FC, Neut, IHC | Mouse IgG1, κ |
| NEUT-296CQ | Mouse Anti-CD2 Recombinant Antibody (clone RPA-2.10) | WB, Neut, FC, IHC, IHC-Fr | Mouse IgG1, κ |
| NEUT-297CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS1/8) | Neut, FC, CyTOF | Mouse IgG1 |
| NEUT-299CQ | Rat Anti-CD2 Recombinant Antibody (clone 12-15) | Neut, FC, IP | Rat IgG1, κ |
| NEUT-300CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2) | FC, FuncS, Neut | Rat IgG2b, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-298CQ | Mouse Anti-CD2 Recombinant Antibody (clone TS218) | Block, FC, IP, WB | Mouse IgG1, κ |
| NEUT-301CQ | Rat Anti-CD2 Recombinant Antibody (clone RM2-5) | FC, IP, Block, Costim | Rat IgG2b, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0542 | Hi-Affi™ Rabbit Anti-CD2 Recombinant Antibody (clone DS542AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0019-LSX-S(P) | Human Anti-CD2 Recombinant Antibody (clone 35.1); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0019-LSX-F(E) | Human Anti-CD2 Recombinant Antibody (clone 35.1); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY48 | AbPlus™ Anti-CD2 Magnetic Beads (TS218) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY84 | Mouse Anti-NHP CD2 Recombinant Antibody (clone RPA-2.10) | IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY21 | CytoStream™ Mouse Anti-CD2 Recombinant Antibody (clone RPA-2.10) | FC | Mouse IgG1, kappa |
| VS13-YC155 | CytoStream™ Rabbit Anti-CD2 Recombinant Antibody (VS13-YC155) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY80 | Mouse Anti-CD2 (clone 35.1) scFv-Fc Chimera | ELISA, Inhib | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC276 | Recombinant Anti-CD2 Vesicular Antibody, EV Displayed (VS-0425-YC276) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1134 | Anti-CD2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1135 | Anti-Mouse CD2 Immunohistochemistry Kit | IHC |
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