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Anti-CD30 (Cac10)-mc-val-cit-PABC-MMAE ADC (SGN-35/brentuximab vedotin) (CAT#: ADC-L036)

This ADC product is composed of an anti-CD30 antibody (clone Cac10) conjuagated via a mc-val-cit-PABC linker to MMAE (cAC10-mc-val-cit-PABC-MMAE). It has demonstrated a response in Lymphomas treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.

Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Figure 4 IHC staining of human tonsil
Figure 4 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Figure 5 IF staining of human cell line EFO-21
Figure 5 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Figure 6 IF staining of human cell line K-562
Figure 6 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Figure 8 Appendix
Figure 8 Appendix
(Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

Specifications

  • Antibody Overview
  • Chimeric anti-CD30 monoclonal antibody, IgG1k
  • Clone
  • Cac10
  • Antibody Conjugation
  • Chimeric murine/human
  • Linker
  • mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Alternative Names
  • CD30; Ki-1; D1S166E

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