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  • Anti-CD30 Antibody-Cytokine Fusion Protein, scFv (HRS3)-IL12-IL2

Anti-CD30 Antibody-Cytokine Fusion Protein, scFv (HRS3)-IL12-IL2 (CAT#: ACFP-SH175)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD30 scFv to IL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the CD30 as well as the biological activity of IL12 and IL2. The tumor-targeted IL12-IL2 fusion protein was superior in activating resting T cells to amplify and secrete pro-inflammatory cytokines compared to targeted IL2 or IL12 alone. This Immunocytokines was designed for treating Hodgkin's disease (HD) anaplastic large cell lymphoma.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Figure 4 IHC staining of human tonsil
Figure 4 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Figure 5 IF staining of human cell line EFO-21
Figure 5 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Figure 6 IF staining of human cell line K-562
Figure 6 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Figure 8 Appendix
Figure 8 Appendix
(Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

Specifications

  • Target
  • CD30
  • Molecule Class
  • scFv-IL12-IL2
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • HRS3
  • Related Disease
  • Hodgkin's disease (HD) anaplastic large cell lymphoma
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Cytokine 2
  • IL2
  • Cytokines 2 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 2 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

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Human Antibody

CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-153 Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Human IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G062E Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G062R Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G062S Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-L041E anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L041R anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA Cytotoxicity assay, Functional assay

Humanized Antibody

CAT Product Name Application Type
TAB-635CL Human Anti-TNFRSF8 Recombinant Antibody (TAB-635CL) ELISA Human IgG
TAB-103LC Anti-Human TNFRSF8 Recombinant Antibody WB, FC, ELISA Humanized antibody
TAB-103LC-S(P) Anti-Human TNFRSF8 Recombinant Antibody scFv Fragment WB, FC, ELISA Humanized antibody
TAB-103LC-F(E) Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment WB, FC, ELISA Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-139LC Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-139LC-1 Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Recombinant Antibody

CAT Product Name Application Type
MOB-0282MZ Recombinant Mouse Anti-Human tumor necrosis factor receptor superfamily, member 8 Antibody (clone Cer-H3) IHC Mouse antibody
HPAB-0459-WJ Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0459-WJ) ELISA, FuncS Mouse IgG
HPAB-1929-FY Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1) ELISA, FC, ADCC Human IgG
FAMAB-0358WJ Human Anti-TNFRSF8 Recombinant Antibody (clone AK30) ELISA, WB Human IgG
VS3-FY272 Recombinant Mouse Anti-TNFRSF8 Antibody (clone 1B1A4G2) ELISA, WB, ICC, FC Mouse IgG1

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0597MZ Chicken Anti-TNFRSF8 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2165CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) FC, Stim, Costim, Block Hamster IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2166CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) Neut, FC Hamster IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3617 Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3617AB) WB, IHC-P Rabbit IgG
MOR-3618 Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3618AB) ELISA Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0329-YC-F(E) Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0329-YC-F(E)) ELISA, FC, Cyt, FuncS Mouse Fab
HPAB-0330-YC-F(E) Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0330-YC-F(E)) ELISA, FC, Cyt, FuncS Human Fab
HPAB-0331-YC-F(E) Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0331-YC-F(E)) ELISA, FC, Cyt, FuncS Mouse Fab
HPAB-0332-YC-F(E) Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0332-YC-F(E)) FC, Cyt Human Fab
HPAB-0333-YC-F(E) Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0333-YC-F(E)) FC, Cyt, FuncS Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-144 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-153 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0459-WJ-S(P) Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0459-WJ-S(P)) ELISA Mouse scFv
HPAB-1929-FY-F(E) Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1); scFv Fragment FC, ELISA Human scFv
HPAB-1930-FY-F(E) Human Anti-TNFRSF8 Recombinant Antibody (clone 2H9); scFv Fragment FC, ELISA Human scFv
HPAB-1931-FY-F(E) Human Anti-TNFRSF8 Recombinant Antibody (clone 5F11); scFv Fragment FC, ELISA Human scFv
FAMAB-0358WJ-S(P) Human Anti-TNFRSF8 Recombinant Antibody (clone AK30); scFv Fragment ELISA, WB Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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