Anti-CD30 Antibody-Cytokine Fusion Protein, scFv (HRS3)-scIL12 (CAT#: ACFP-SH127)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD30 scFv to scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD30 as well as the biological activity of IL12. The anti-CD30-IL12 antibody-cytokine fusion protein is composed of a CD30 binding domain (HRS3-scFv) linked to p40-p35 murine single chain IL12. After binding to CD30+ H/RS cells, the fusion protein stimulates T cells to secrete IFN-γ, a predominant Th1 cytokine, and induces NK cells to lyse CD30+ cells with high efficiency. These properties make the HRS3-scFv-IL12 fusion protein suitable for the specific immunotherapy of Hodgkin's lymphoma. This immunocytokine was designed for treating CD30-positive lymphoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • CD30
  • Molecule Class
  • scFv-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • HRS3
  • Related Disease
  • CD30-positive lymphoma
  • Cytokine 1
  • scIL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-153 Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Human IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G062E Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G062R Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G062S Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-L041E anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L041R anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA Cytotoxicity assay, Functional assay

Humanized Antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-139LC Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-139LC-1 Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0597MZ Chicken Anti-TNFRSF8 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2165CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) FC, Stim, Costim, Block Hamster IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2166CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) Neut, FC Hamster IgG1, κ

Rabbit Monoclonal Antibody

Recombinant Antibody

CAT Product Name Application Type
HPAB-0329-YC Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0329-YC) ELISA, FC, Cyt, FuncS, Inhib Mouse IgG
HPAB-0330-YC Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0330-YC) ELISA, FC, Cyt, FuncS, Inhib Chimeric (mouse/human) IgG1, κ
HPAB-0331-YC Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0331-YC) ELISA, FC, Cyt, FuncS, Inhib Mouse IgG
HPAB-0332-YC Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0332-YC) FC, Cyt, FuncS Human IgG1, κ
HPAB-0333-YC Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0333-YC) FC, Cyt, FuncS Human IgG, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-144 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-153 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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