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anti-CD40LG immunotoxin MR1 (scFv)-PAP (AGTO-L051P)

This immunotoxin was achieved by conjugating/fusing the Anti-CD40LG scFv to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD40L expressing cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of T-cell malignancies.      
Datasheet
Specifications
Host
Mouse
Species Reactivity
Human
Clone
MR1
Molecule Class
scFv-PAP
Toxin Description
Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T-cell malignancies
Target
Alternative Names
CD40LG; CD40 ligand; IGM; IMD3; TRAP; gp39; CD154; CD40L
Entrez Gene ID
959
UniProt ID
P29965

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Anti-Human CD40LG Therapeutic Antibody Fab Fragment (DOM-24)    ( TAB-220LC-F(E) )
Anti-Human CD40LG Therapeutic Antibody scFv Fragment (DOM-2)    ( TAB-213LC-S(P) )
Anti-Human CD40LG Therapeutic Antibody scFv Fragment (IDEC131/E6040)    ( TAB-211LC-S(P) )
Recombinant Humanized Anti-CD40LG Antibody Fab Fragment (5C8 )    ( PFBW-020 )
Recombinant Human Anti-CD40LG Antibody scFv Fragment    ( NS-022CN-S(P) )
Recombinant Humanized Anti-CD40LG Antibody (h24–31)    ( HPAB-0178-YC )
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