Anti-Cd40lg immunotoxin LL2 (IgG)-PE

Name: Anti-Cd40lg immunotoxin LL2 (IgG)-PE
SKU: AGTO-G080E
Rating: 5 (1 reviews)

CAT#: AGTO-G080E

This immunotoxin was achieved by conjugating/fusing the Anti-Cd40lg monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating B-cell lymphoma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg

Normal Tissue Figure 3 Colon

Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg

Normal Tissue Figure 4 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG

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Specifications

Host Species
Hamster

Species Reactivity
Mouse

Clone
LL2

Molecule Class
L kappa; IgG-PE

Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
B-cell lymphoma

Target

Alternative Names
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Cd40lg; CD40 ligand; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE104

Gene ID
21947

UniProt ID
P27548

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-G080E.pdf

MSDS

MSDS - AGTO-G080E.pdf

COA

Certificate of Analysis Lookup

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CAT
Product Name

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Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
AGTO-G081E	Anti-Cd40lg immunotoxin LL2 (Fab)-PE	Cytotoxicity assay, Function study
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CAT	Product Name	Application	Type
PSBW-020	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (PSBW-020)	Neut	Human scFv
HPAB-0179-YC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0179-YC-S(P))	ELISA	Human scFv
FAMAB-0135-YC-S(P)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); scFv Fragment	ELISA	Hamster scFv
HPAB-0880LY-S(P)	Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0880LY-S(P))	FC	Mouse scFv
HPAB-0585-WJ-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0585-WJ-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-211LC	Human Anti-CD40LG Recombinant Antibody (TAB-211LC)	ELISA	Human IgG, κ
TAB-210LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-210LC-S(P))	ELISA	Humanized scFv
TAB-211LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-211LC-S(P))	ELISA	Human scFv
TAB-210LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-210LC-F(E))	ELISA	Humanized Fab
TAB-211LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-211LC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application
TAB-212LC	Mouse Anti-Human CD40LG Recombinant Antibody (ABI793)	Block
TAB-212LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (ABI793)	ELISA
TAB-212LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (ABI793)	ELISA

CAT	Product Name	Application	Type
TAB-225LC	Anti-Human CD40LG Recombinant Antibody (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)

CAT	Product Name	Application
TAB-213LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-213LC-F(E))	FC, ELISA, RBA
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TAB-215LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-215LC-F(E))	FC, ELISA, RBA
TAB-216LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-216LC-F(E))	FC, ELISA, RBA
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CAT	Product Name	Application	Type
NEUT-369CQ	Mouse Anti-CD40LG Recombinant Antibody (clone CBL300)	FC, IHC, CyTOF, Neut, WB	Mouse IgG2b
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CAT	Product Name	Application	Type
MOR-0561	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS561AB)	WB, FC	Rabbit IgG
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CAT	Product Name	Application	Type
EPAF-0610LC	Mouse Anti-CD40LG Recombinant Antibody (clone h5c8)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
NS-022CN	Human Anti-CD40LG Recombinant Antibody (NS-022CN)	ELISA, FC	Human IgG
NS-022CN-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (NS-022CN-F(E))	ELISA, FC	Human Fab
NS-022CN-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (NS-022CN-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
HPAB-0744LY-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0744LY-F(E))	ELISA	Human Fab
HPAB-0880LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0880LY-F(E))	FC	Mouse Fab
HPAB-0881LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0881LY-F(E))	FC	Mouse Fab
HPAB-0882LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0882LY-F(E))	FC	Mouse Fab
HPAB-0585-WJ-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0585-WJ-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-027	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-027)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-876	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS13-YC164	CytoStream™ Rabbit Anti-CD40LG Recombinant Antibody (VS13-YC164)	WB, ICC, IF, IHC-P, FC	Rabbit IgG

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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