Anti-Human CD40 ligand Recombinant Antibody (Toralizumab)

Name: Anti-Human CD40 ligand Recombinant Antibody (Toralizumab)
SKU: TAB-876
Rating: 5 (1 reviews)

CAT#: TAB-876

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. Toralizumab was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenstrom's macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin's disease).

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg

Normal Tissue Figure 3 Colon

Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg

Normal Tissue Figure 4 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1 - kappa

Species Reactivity
Human

Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.

CAS
252662-47-8

Generic Name
toralizumab

MW
148,426 Daltons

Related Disease
Systemic lupus erythematosus (SLE)

Product Property

Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.

Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Target

Alternative Names
toralizumab;252662-47-8;IDEC-131;E6040;IDEC 131;CD40LG;CD40 ligand;HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome);CD40 antigen ligand;CD40L;CD154;gp39;hCD40L;hyper IgM syndrome;T B cell activating molecule;T

Gene ID
959

UniProt ID
P29965

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(Creative Biolabs Cat# TAB-876, RRID: AB_3112012)

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Biosimilar Overview

Please refer to Toralizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Toralizumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-876.pdf

MSDS

MSDS - TAB-876.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Toralizumab"

Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. It was a humanized monoclonal antibody and an immunosuppressive drug.

DrugMonitor™ Anti-Toralizumab Antibody (VS-1224-YC1223)
Toralizumab (IDEC 131) was a humanized monoclonal antibody and immunosuppressive drug. The DrugMonitor™ Anti-Toralizumab Antibody (VS-1224-YC1223) is an anti-drug antibody (ADA) against Toralizumab. This drug-based antibody is raised in mice immunized with the Toralizumab. The anti-Toralizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Toralizumab in samples.

See other products for "CD40LG"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1071z	Mouse Anti-CD40LG Recombinant Antibody (clone 18C1)	ELISA, FC, FuncS, ICC, IF	Mouse IgG1
PABW-020	Human Anti-CD40LG Recombinant Antibody (PABW-020)	Neut	Human IgG1, κ
VS3-XY339	Mouse Anti-CD40LG Recombinant Antibody, FITC (clone 4AM91)	FC, IF	Mouse IgG1
VS3-XY340	Mouse Anti-CD40LG Recombinant Antibody, PE (clone 4AM91)	FC, IF	Mouse IgG1
VS3-XY341	Mouse Anti-CD40LG Recombinant Antibody (clone 4AM91)	FC, IF	Mouse IgG1

CAT	Product Name	Application	Type
TAB-027	Anti-Human CD40L Recombinant Antibody (TAB-027)	IF, IP, Neut, FuncS, ELISA, FC, ICC	IgG1 - kappa
TAB-211LC	Human Anti-CD40LG Recombinant Antibody (TAB-211LC)	ELISA	Human IgG, κ
TAB-210LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-210LC-S(P))	ELISA	Humanized scFv
TAB-211LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-211LC-S(P))	ELISA	Human scFv
TAB-210LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-210LC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application
AGTO-G080E	Anti-Cd40lg immunotoxin LL2 (IgG)-PE	Cytotoxicity assay, Function study
AGTO-G081E	Anti-Cd40lg immunotoxin LL2 (Fab)-PE	Cytotoxicity assay, Function study
AGTO-L051P	anti-CD40LG immunotoxin MR1 (scFv)-PAP	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
PFBW-020	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (PFBW-020)	Neut	Human Fab
HPAB-0880LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0880LY-F(E))	FC	Mouse Fab
HPAB-0881LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0881LY-F(E))	FC	Mouse Fab
HPAB-0882LY-F(E)	Mouse Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0882LY-F(E))	FC	Mouse Fab
HPAB-0585-WJ-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0585-WJ-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
PSBW-020	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (PSBW-020)	Neut	Human scFv
HPAB-0179-YC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0179-YC-S(P))	ELISA	Human scFv
FAMAB-0135-YC-S(P)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); scFv Fragment	ELISA	Hamster scFv
HPAB-0744LY-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0744LY-S(P))	ELISA	Human scfv
HPAB-0585-WJ-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0585-WJ-S(P))	ELISA	Human scFv

CAT	Product Name	Application
TAB-212LC	Mouse Anti-Human CD40LG Recombinant Antibody (ABI793)	Block
TAB-212LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (ABI793)	ELISA
TAB-212LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (ABI793)	ELISA

CAT	Product Name	Application	Type
TAB-225LC	Anti-Human CD40LG Recombinant Antibody (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)

CAT	Product Name	Application
TAB-213LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-213LC-S(P))	FC, ELISA, RBA
TAB-214LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-214LC-S(P))	FC, ELISA, RBA
TAB-215LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-215LC-S(P))	FC, ELISA, RBA
TAB-216LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-216LC-S(P))	FC, ELISA, RBA
TAB-217LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-217LC-S(P))	FC, ELISA, RBA

CAT	Product Name	Application	Type
NEUT-368CQ	Mouse Anti-CD40LG Recombinant Antibody (clone 24-31)	FC, Block, IF	Mouse IgG1, κ
NEUT-375CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MR1)	IHC-Fr, FC, IP, Block	Hamster IgG1, κ
NEUT-377CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MAB0820)	Block, FC, IHC-Fr	Hamster IgG

CAT	Product Name	Application	Type
NEUT-369CQ	Mouse Anti-CD40LG Recombinant Antibody (clone CBL300)	FC, IHC, CyTOF, Neut, WB	Mouse IgG2b
NEUT-370CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL2)	Neut, ELISA, FC, FuncS, IF	Mouse IgG1
NEUT-371CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL48)	Neut, FuncS, IF	Mouse IgG2a
NEUT-372CQ	Mouse Anti-CD40LG Recombinant Antibody (NEUT-372CQ)	Neut	Mouse IgG2b
NEUT-374CQ	Rat Anti-CD40LG Recombinant Antibody (clone CBL719)	FC, CyTOF, Neut	Rat IgG2a

CAT	Product Name	Application	Type
MOR-0561	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS561AB)	WB, FC	Rabbit IgG
MOR-0562	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS562AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0610LC	Mouse Anti-CD40LG Recombinant Antibody (clone h5c8)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
NS-022CN	Human Anti-CD40LG Recombinant Antibody (NS-022CN)	ELISA, FC	Human IgG
NS-022CN-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (NS-022CN-F(E))	ELISA, FC	Human Fab
NS-022CN-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (NS-022CN-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-027	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-027)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-876	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS13-YC164	CytoStream™ Rabbit Anti-CD40LG Recombinant Antibody (VS13-YC164)	WB, ICC, IF, IHC-P, FC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0425-FY79	Human Anti-CD40LG (clone YMF323.6) scFv-Fc Chimera	FC, ELISA, IHC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC389	Recombinant Anti-CD40LG Vesicular Antibody, EV Displayed (VS-0425-YC389)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1182	Anti-CD40LG Immunohistochemistry Kit	IHC
VS-0525-XY1183	Anti-Mouse CD40LG Immunohistochemistry Kit	IHC

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