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Anti-Human CD40 ligand Recombinant Antibody (Toralizumab) (CAT#: TAB-876)

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. Toralizumab was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenstrom's macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin's disease).


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Subcellular Location
Figure 1 IF staining of human cell line JURKAT
Figure 1 IF staining of human cell line JURKAT
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg
Figure 2 IF staining of human cell line HEL
Figure 2 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg
Normal Tissue
Figure 3 Colon
Figure 3 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
Figure 5 RNA cell line category: Cell line enriched (MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
  • CAS
  • 252662-47-8
  • Generic Name
  • toralizumab
  • MW
  • 148,426 Daltons
  • Related Disease
  • Systemic lupus erythematosus (SLE)

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Target

  • Alternative Names
  • toralizumab;252662-47-8;IDEC-131;E6040;IDEC 131;CD40LG;CD40 ligand;HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome);CD40 antigen ligand;CD40L;CD154;gp39;hCD40L;hyper IgM syndrome;T B cell activating molecule;T

Related Resources

  • Biosimilar Overview
Please refer to Toralizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Toralizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Toralizumab"

Afuco™ Anti-CD40LG ADCC Recombinant Antibody (Toralizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD40 ligand. Toralizumab was a humanized monoclonal antibody and an immunosuppressive drug.

See other products for "CD40LG"

Humanized Antibody

CAT Product Name Application Type
TAB-027 Anti-Human CD40L Recombinant Antibody (Ruplizumab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG1 - kappa
TAB-211LC Human Anti-CD40LG Recombinant Antibody (TAB-211LC) ELISA Human IgG, κ
TAB-210LC-S(P) Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-210LC-S(P)) ELISA Humanized scFv
TAB-211LC-S(P) Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-211LC-S(P)) ELISA Human scFv
TAB-210LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-210LC-F(E)) ELISA Humanized Fab

Immunotoxin

CAT Product Name Application Type
AGTO-G080E Anti-Cd40lg immunotoxin LL2 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G081E Anti-Cd40lg immunotoxin LL2 (Fab)-PE Cytotoxicity assay, Function study
AGTO-L051P anti-CD40LG immunotoxin MR1 (scFv)-PAP Cytotoxicity assay, Functional assay

Fab Fragment Antibody

CAT Product Name Application Type
PFBW-020 Human Anti-CD40LG Recombinant Antibody; Fab Fragment (PFBW-020) Neut Human Fab
HPAB-0179-YC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0179-YC-F(E)) ELISA Human Fab
FAMAB-0135-YC-F(E) Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); Fab Fragment ELISA Hamster Fab
HPAB-0744LY-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0744LY-F(E)) ELISA Human Fab
HPAB-0585-WJ-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0585-WJ-F(E)) ELISA Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-212LC Mouse Anti-Human CD40LG Recombinant Antibody (ABI793) Block
TAB-212LC-S(P) Anti-Human CD40LG Recombinant Antibody scFv Fragment (ABI793) ELISA
TAB-212LC-F(E) Anti-Human CD40LG Recombinant Antibody Fab Fragment (ABI793) ELISA

Chimeric Antibody

CAT Product Name Application Type
TAB-225LC Anti-Human CD40LG Recombinant Antibody (YMF323.6) ELISA Chimeric antibody (hamster/human)
TAB-225LC-S(P) Anti-Human CD40LG Recombinant Antibody scFv Fragment (YMF323.6) ELISA Chimeric antibody (hamster/human)
TAB-225LC-F(E) Anti-Human CD40LG Recombinant Antibody Fab Fragment (YMF323.6) ELISA Chimeric antibody (hamster/human)

Human Antibody

CAT Product Name Application Type
TAB-213LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-213LC-F(E)) FC, ELISA, RBA
TAB-214LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-214LC-F(E)) FC, ELISA, RBA
TAB-215LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-215LC-F(E)) FC, ELISA, RBA
TAB-216LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-216LC-F(E)) FC, ELISA, RBA
TAB-217LC-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-217LC-F(E)) FC, ELISA, RBA

Blocking Antibody

CAT Product Name Application Type
NEUT-368CQ Mouse Anti-CD40LG Recombinant Antibody (clone 24-31) FC, Block, IF Mouse IgG1, κ
NEUT-375CQ Hamster Anti-CD40LG Recombinant Antibody (clone MR1) IHC-Fr, FC, IP, Block Hamster IgG1, κ
NEUT-377CQ Hamster Anti-CD40LG Recombinant Antibody (clone MAB0820) Block, FC, IHC-Fr Hamster IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-369CQ Mouse Anti-CD40LG Recombinant Antibody (clone CBL300) FC, IHC, CyTOF, Neut, WB Mouse IgG2b
NEUT-370CQ Mouse Anti-CD40LG Recombinant Antibody (clone LL2) Neut, ELISA, FC, FuncS, IF Mouse IgG1
NEUT-371CQ Mouse Anti-CD40LG Recombinant Antibody (clone LL48) Neut, FuncS, IF Mouse IgG2a
NEUT-372CQ Mouse Anti-CD40LG Recombinant Antibody (clone 13H5) Neut Mouse IgG2b
NEUT-374CQ Rat Anti-CD40LG Recombinant Antibody (clone CBL719) FC, CyTOF, Neut Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0561 Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS561AB) WB, FC Rabbit IgG
MOR-0562 Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS562AB) ELISA Rabbit IgG

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0610LC Mouse Anti-CD40LG Recombinant Antibody (clone h5c8) ELISA Mouse IgG1

Recombinant Antibody

CAT Product Name Application Type
HPAB-0179-YC Human Anti-CD40LG Recombinant Antibody (HPAB-0179-YC) ELISA Human IgG1
FAMAB-0135YC Hamster Anti-CD40LG Recombinant Antibody (clone mr-1) ELISA Hamster IgG
HPAB-0880LY Mouse Anti-CD40LG Recombinant Antibody (HPAB-0880LY) FC Mouse IgG1
MRO-0304-CN Rabbit Anti-CD40LG Recombinant Antibody (clone JM11-34) WB, IF, IHC, FC Rabbit IgG
VS3-CJ861 Mouse Anti-CD40LG Recombinant Antibody (clone M91) IF, FC Mouse IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0179-YC-S(P) Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0179-YC-S(P)) ELISA Human scFv
HPAB-0880LY-S(P) Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0880LY-S(P)) FC Mouse scFv
HPAB-0881LY-S(P) Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0881LY-S(P)) FC Mouse scFv
HPAB-0882LY-S(P) Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0882LY-S(P)) FC Mouse scFv
HPAB-0585-WJ-S(P) Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0585-WJ-S(P)) ELISA Human scFv

Neuroscience Antibody

CAT Product Name Application Type
NS-022CN Human Anti-CD40LG Recombinant Antibody (NS-022CN) ELISA, FC Human IgG
NS-022CN-F(E) Human Anti-CD40LG Recombinant Antibody; Fab Fragment (NS-022CN-F(E)) ELISA, FC Human Fab
NS-022CN-S(P) Human Anti-CD40LG Recombinant Antibody; scFv Fragment (NS-022CN-S(P)) ELISA, FC Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-027 Afuco™ Anti-CD40LG ADCC Recombinant Antibody (Ruplizumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-876 Afuco™ Anti-CD40LG ADCC Recombinant Antibody (Toralizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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