Creative Biolabs Recombinant Antibodies
Products
  1. Home
  2. Cd40lg
  3. Anti-Cd40lg immunotoxin LL2 (Fab)-PE

Anti-Cd40lg immunotoxin LL2 (Fab)-PE (AGTO-G081E)

This immunotoxin was achieved by conjugating/fusing the Anti-Cd40lg Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating B-cell lymphoma.      
  • Datasheet

Specifications
Host
Hamster
Species Reactivity
Mouse
Clone
LL2
Molecule Class
Fab-PE
Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
B-cell lymphoma
Target
Alternative Names
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1
Entrez Gene ID
21947
UniProt ID
P27548

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "Cd40lg"
Recombinant Rat Anti-CD40LG Antibody (CBL719)    ( NEUT-374CQ )
Recombinant Anti-Human CD40LG Antibody scFv Fragment    ( MOB-1071z-S(P) )
Anti-Human CD40LG Therapeutic Antibody (ABI793)    ( TAB-127CL )
Recombinant Hamster Anti-CD40LG Antibody Fab Fragment (mr-1)    ( FAMAB-0135-YC-F(E) )
Anti-Human CD40LG Therapeutic Antibody scFv Fragment (YMF323.6)    ( TAB-225LC-S(P) )
Anti-Human CD40LG Therapeutic Antibody (DOM-2)    ( TAB-213LC )
Recombinant Human Anti-CD40LG Antibody scFv Fragment (DMS0507)    ( HPAB-0179-YC-S(P) )
Anti-Human CD40LG Therapeutic Antibody scFv Fragment (DOM-30)    ( TAB-222LC-S(P) )
>> MORE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
           

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved