Anti-Cd40lg immunotoxin LL2 (Fab)-PE

Name: Anti-Cd40lg immunotoxin LL2 (Fab)-PE
SKU: AGTO-G081E
Rating: 5 (1 reviews)

CAT#: AGTO-G081E

This immunotoxin was achieved by conjugating/fusing the Anti-Cd40lg Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating B-cell lymphoma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2010_G3_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line HEL

Immunofluorescent staining of human cell line HEL shows localization to golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/2069_B6_2_blue_green.jpg

Normal Tissue Figure 3 Colon

Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_3.jpg

Normal Tissue Figure 4 Lymph node

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72480/169295_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102245-CD40LG

❮

❯

Specifications

Host Species
Hamster

Species Reactivity
Mouse

Clone
LL2

Molecule Class
Fab-PE

Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
B-cell lymphoma

Target

Alternative Names
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Cd40lg; CD40 ligand; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE105

Gene ID
21947

UniProt ID
P27548

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for AGTO-G081E. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-G081E.pdf

MSDS

MSDS - AGTO-G081E.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone LL2"

CAT
Product Name

See other products for "CD40LG"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-027	Anti-Human CD40L Recombinant Antibody (TAB-027)	IF, IP, Neut, FuncS, ELISA, FC, ICC	IgG1 - kappa
TAB-211LC	Human Anti-CD40LG Recombinant Antibody (TAB-211LC)	ELISA	Human IgG, κ
TAB-210LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-210LC-S(P))	ELISA	Humanized scFv
TAB-211LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-211LC-S(P))	ELISA	Human scFv
TAB-210LC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (TAB-210LC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
AGTO-G080E	Anti-Cd40lg immunotoxin LL2 (IgG)-PE	Cytotoxicity assay, Function study
AGTO-L051P	anti-CD40LG immunotoxin MR1 (scFv)-PAP	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
PABW-020	Human Anti-CD40LG Recombinant Antibody (PABW-020)	Neut	Human IgG1, κ
MOB-0503CT	Mouse Anti-CD40LG Recombinant Antibody (clone 3C20)	ELISA, WB	Mouse IgG1
FAMAB-0135YC	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1)	ELISA	Hamster IgG
HPAB-0880LY	Mouse Anti-CD40LG Recombinant Antibody (HPAB-0880LY)	FC	Mouse IgG1
HPAB-0881LY	Mouse Anti-CD40LG Recombinant Antibody (HPAB-0881LY)	FC	Mouse IgG1

CAT	Product Name	Application	Type
PFBW-020	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (PFBW-020)	Neut	Human Fab
HPAB-0179-YC-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0179-YC-F(E))	ELISA	Human Fab
FAMAB-0135-YC-F(E)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); Fab Fragment	ELISA	Hamster Fab
HPAB-0744LY-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0744LY-F(E))	ELISA	Human Fab
HPAB-0585-WJ-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (HPAB-0585-WJ-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
PSBW-020	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (PSBW-020)	Neut	Human scFv
FAMAB-0135-YC-S(P)	Hamster Anti-CD40LG Recombinant Antibody (clone mr-1); scFv Fragment	ELISA	Hamster scFv
HPAB-0744LY-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0744LY-S(P))	ELISA	Human scfv
HPAB-0880LY-S(P)	Mouse Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0880LY-S(P))	FC	Mouse scFv
HPAB-0585-WJ-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (HPAB-0585-WJ-S(P))	ELISA	Human scFv

CAT	Product Name	Application
TAB-212LC	Mouse Anti-Human CD40LG Recombinant Antibody (ABI793)	Block
TAB-212LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (ABI793)	ELISA
TAB-212LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (ABI793)	ELISA

CAT	Product Name	Application	Type
TAB-225LC	Anti-Human CD40LG Recombinant Antibody (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-S(P)	Anti-Human CD40LG Recombinant Antibody scFv Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)
TAB-225LC-F(E)	Anti-Human CD40LG Recombinant Antibody Fab Fragment (YMF323.6)	ELISA	Chimeric antibody (hamster/human)

CAT	Product Name	Application
TAB-213LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-213LC-S(P))	FC, ELISA, RBA
TAB-214LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-214LC-S(P))	FC, ELISA, RBA
TAB-215LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-215LC-S(P))	FC, ELISA, RBA
TAB-216LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-216LC-S(P))	FC, ELISA, RBA
TAB-217LC-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (TAB-217LC-S(P))	FC, ELISA, RBA

CAT	Product Name	Application	Type
NEUT-368CQ	Mouse Anti-CD40LG Recombinant Antibody (clone 24-31)	FC, Block, IF	Mouse IgG1, κ
NEUT-375CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MR1)	IHC-Fr, FC, IP, Block	Hamster IgG1, κ
NEUT-377CQ	Hamster Anti-CD40LG Recombinant Antibody (clone MAB0820)	Block, FC, IHC-Fr	Hamster IgG

CAT	Product Name	Application	Type
NEUT-369CQ	Mouse Anti-CD40LG Recombinant Antibody (clone CBL300)	FC, IHC, CyTOF, Neut, WB	Mouse IgG2b
NEUT-370CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL2)	Neut, ELISA, FC, FuncS, IF	Mouse IgG1
NEUT-371CQ	Mouse Anti-CD40LG Recombinant Antibody (clone LL48)	Neut, FuncS, IF	Mouse IgG2a
NEUT-372CQ	Mouse Anti-CD40LG Recombinant Antibody (NEUT-372CQ)	Neut	Mouse IgG2b
NEUT-374CQ	Rat Anti-CD40LG Recombinant Antibody (clone CBL719)	FC, CyTOF, Neut	Rat IgG2a

CAT	Product Name	Application	Type
MOR-0561	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS561AB)	WB, FC	Rabbit IgG
MOR-0562	Hi-Affi™ Rabbit Anti-CD40LG Recombinant Antibody (clone DS562AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
EPAF-0610LC	Mouse Anti-CD40LG Recombinant Antibody (clone h5c8)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
NS-022CN	Human Anti-CD40LG Recombinant Antibody (NS-022CN)	ELISA, FC	Human IgG
NS-022CN-F(E)	Human Anti-CD40LG Recombinant Antibody; Fab Fragment (NS-022CN-F(E))	ELISA, FC	Human Fab
NS-022CN-S(P)	Human Anti-CD40LG Recombinant Antibody; scFv Fragment (NS-022CN-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-027	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-027)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-876	Afuco™ Anti-CD40LG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-876)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS13-YC164	CytoStream™ Rabbit Anti-CD40LG Recombinant Antibody (VS13-YC164)	WB, ICC, IF, IHC-P, FC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0425-FY79	Human Anti-CD40LG (clone YMF323.6) scFv-Fc Chimera	FC, ELISA, IHC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC389	Recombinant Anti-CD40LG Vesicular Antibody, EV Displayed (VS-0425-YC389)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1182	Anti-CD40LG Immunohistochemistry Kit	IHC
VS-0525-XY1183	Anti-Mouse CD40LG Immunohistochemistry Kit	IHC

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 3 Anti-Human IL17RA Antibody (TAB-134) in DB

Human Anti-IL17RA Recombinant Antibody (TAB-134) (CAT# TAB-134)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 3 Anti-Human TNF beta Antibody (TAB-071) in DB

Anti-Human TNF beta Recombinant Antibody (TAB-071) (CAT# TAB-071)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 5 GPNMB Recombinant Antibody (TAB-751) in ELISA

Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) (CAT# TAB-751)
Application: WB, IF, IP, Neut, FuncS, ELISA, FC

Figure 5 Anti-Human ITGAV Recombinant Antibody (TAB-H01) in ELISA

Anti-Human ITGAV Recombinant Antibody (Abituzumab) (CAT# TAB-H01)
Application: Inhib, Agonist

Figure 3 Anti-Human NCAM1 Therapeutic Antibody (TAB-188) in ELISA

Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) (CAT# TAB-188)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-ERBB2 Recombinant Antibody (Margetuximab) (TAB-761) in SPR

Anti-ERBB2 Recombinant Antibody (Margetuximab) (CAT# TAB-761)
Application: IF, IP, Neut, FuncS, ELISA, FC, WB

Figure 3 Anti-Human Abeta Antibody in DB

Anti-Human Abeta Recombinant Antibody (TAB-229) (CAT# TAB-229)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC

Figure 2 Selectin P Recombinant Antibody (TAB-246) in ELISA

Anti-Human selectin P Recombinant Antibody (Inclacumab) (CAT# TAB-246)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human CD70 Recombinant Antibody (TAB-H76) in ELISA

Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) (CAT# TAB-H76)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Recombinant Human Anti-RSV Antibody (PABL-321) in SDS-PAGE

Recombinant Human Anti-RSV Antibody (AM14) (CAT# PABL-321)
Application: WB, ELISA, Neut, FuncS

Figure 5 Mouse Anti-His Tag Recombinant Antibody Fab Fragment (PFBL-134) in HPLC

Mouse Anti-His Tag Recombinant Antibody (clone YC103); Fab Fragment (CAT# PFBL-134)
Application: WB, ELISA, FuncS

Figure 4 Anti-Human CD59 Recombinant Antibody Fab Fragment (TAB-321LC-F(E)) in DB

Anti-Human CD59 Recombinant Antibody Fab Fragment ((ch)AR36A36.11.1) (CAT# TAB-321LC-F(E))
Application: WB, ELISA

Figure 2 Anti-Human SLC34A2 Recombinant Antibody (TAB-467MZ) in HPLC

Mouse Anti-SLC34A2 Recombinant Antibody (TAB-467MZ) (CAT# TAB-467MZ)
Application: FC, Inhib

Figure 3 Anti-Human ERBB2 Recombinant Antibody (TAB-558MZ) in WB

Human Anti-NOTCH3 Recombinant Antibody (TAB-558MZ) (CAT# TAB-558MZ)
Application: Inhib, Neut

Figure 4 Recombinant Mouse Anti-Integrin alpha 4 Antibody (ACT-1), Fc silenced (PABX-122-FcS) in ELISA

Recombinant Mouse Anti-Integrin alpha 4 Antibody (ACT-1) (CAT# PABX-122)
Application: Neut, FuncS

Figure 2 Mouse Anti-TREM2 Recombinant Antibody (HPAB-0154-CN) in HPLC

Mouse Anti-TREM2 Recombinant Antibody (HPAB-0154-CN) (CAT# HPAB-0154-CN)
Application: WB, ELISA, FC, IHC, IF, IP

Figure 2 Recombinant Mouse Anti-EBV gH/gL Antibody (PABC-524) in HPLC

Recombinant Mouse Anti-EBV gH/gL Antibody (E1D1) (CAT# PABC-524)
Application: ELISA, FC, Neut, Inhib

Figure 2 Mouse Anti-PTPRC Recombinant Antibody (HPAB-0258-FY) in HPLC

Mouse Anti-PTPRC Recombinant Antibody (HPAB-0258-FY) (CAT# HPAB-0258-FY)
Application: ELISA

Figure 2 Mouse Anti-FSTL3 Recombinant Antibody (HPAB-N0094-YC) in HPLC

Mouse Anti-FSTL3 Recombinant Antibody (HPAB-N0094-YC) (CAT# HPAB-N0094-YC)
Application: Neut, WB

Figure 3 Anti-TPO Recombinant Antibody (FAMAB-0014JF) in DB

Human Anti-TPO Recombinant Antibody (clone B8) (CAT# FAMAB-0014JF)
Application: WB, ELISA, IHC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.