Afuco™ Anti-Human CTLA4 ADCC Recombinant Antibody (JMW-3B3), ADCC Enhanced (CAT#: AFC-185CL)

Anti-CTLA4 ADCC Enhanced Antibody (JMW-3B3) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a monoclonal antibody to investigate whether sCTLA-4 is important in controlling immune responses particularly in SLE patients. The anti-sCTLA-4 antibody is currently being humanised as a potential therapy for the treatment of some cancers.


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Figure 1 Comparison of selective sCTLA-4 Ab with conventional anti-CTLA-4 mAb Ab blockade on PBMC effector T-cell responses.

Figure 1 Comparison of selective sCTLA-4 Ab with conventional anti-CTLA-4 mAb Ab blockade on PBMC effector T-cell responses.

(A) Dose–response effect of anti-sCTLA-4 mAb, JMW-3B3, on healthy donor resting PBMCs (left) is shown. Data are shown as mean + SEM of three replicates and are representative of three donors tested. Dose response effect of anti-sCTLA-4 mAb compared with four conventional "pan-specific" anti-CTLA-4 mAbs on healthy donor resting PBMCs is shown (right). Data are shown as mean + SEM of three replicates and are representative of three donors tested. (B) Summary comparison of anti-sCTLA-4 mAb with conventional anti-CTLA-4 mAb blockade (clone: BNI3) on PBMC responses from 10 donors. Left panels — resting cells with isotype Ab, anti-sCTLA-4 mAb, JMW3-B3, and anti-CTLA-4 mAb, BNI3; right panels — show data from cells stimulated with PPD (n = 10; **p < 0.01; *p < 0.05, ns: not significant, Wilcoxon).

Ward,F.J.,Dahal,L.N.,Wijesekera,S. K., Abdul-Jawad,S.K.,Kaewarpai,T.,Xu,H.,& Barker,R.N.(2013).The soluble isoform of CTLA-4 as a regulator of T-cell responses.European journal of immunology, 43(5), 1274-1285.


Specifications

  • Host Species
  • Mouse
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by analysis by RP-HPLC
  • Storage
  • Store at –20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.

Target

  • Alternative Names
  • CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CTLA4"

Human Antibody

CAT Product Name Application Type
TAB-067 Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1 - kappa
TAB-206 Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) WB, IF, IP, Neut, FuncS, ELISA, FC IgG2

Immunotoxin

CAT Product Name Application Type
AGTO-G015E Anti-CTLA4 immunotoxin (scFv)-PE Cytotoxicity assay, Function study
AGTO-G015S Anti-CTLA4 immunotoxin (scFv)-Sap Cytotoxicity assay, Function study
AGTO-G015M Anti-CTLA4 immunotoxin (scFv)-Mel Cytotoxicity assay, Function study

Rat Antibody

CAT Product Name Application Type
TAB-195CL Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) ELISA Mouse IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-085MZ Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ Anti-Human CTLA4 Recombinant Antibody (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-086MZ-S(P) Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.C) ELISA, FC Chimeric antibody (mouse/human)
TAB-085MZ-F(E) Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) ELISA, FC Chimeric antibody (mouse/human)

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0855 Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-067 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-206 Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced IF, IP, Neut, FuncS, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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