Afuco™ Anti-Human F3 ADCC Recombinant Antibody (MORAb-066), ADCC Enhanced (CAT#: AFC-246CL)
Anti-F3 ADCC Enhanced Antibody (MORAb-066) is an ADCC enhanced antibody produced by our Afuco™ platform. MORAb-066 is a humanized monoclonal antibody that targets tissue factor (TF), which is a protein whose role under normal conditions is to support blood coagulation. In cancer, it has been shown that TF is a membrane-bound antigen expressed by tumor endothelial cells that is hypothesized to play a role in promoting tumor angiogenesis and growth.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49292/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49292/if_selected.jpg
Figure 2 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69132/1343_C8_1_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69132/1343_C8_1_selected.jpg
Figure 3 IHC staining of human nasopharynx
(Immunohistochemical staining of human nasopharynx shows strong cytoplasmic positivity in respiratory epithelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/ihc_selected.jpg
(Immunohistochemical staining of human nasopharynx shows strong cytoplasmic positivity in respiratory epithelial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/ihc_selected.jpg
Figure 4 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_B_7_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_B_7_5.jpg
Figure 5 Testis
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_A_6_6.jpg
(Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_A_6_6.jpg
Figure 6 Placenta
(Decidual cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_A_2_7.jpg
(Decidual cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9438/27291_A_2_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117525-F3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117525-F3
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117525-F3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117525-F3
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Pancreatic Cancer
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor
- Gene ID
- 2152
- UniProt ID
- P13726
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-471 | Human Anti-F3 Recombinant Antibody (clone 10H10) | WB, IF, FuncS | Human IgG |
| HPAB-0172CQ | Human Anti-F3 Recombinant Antibody (HPAB-0172CQ) | ELISA, FC, ADCC | Chimeric (mouse/human) IgG1 |
| HPAB-0173CQ | Human Anti-F3 Recombinant Antibody (HPAB-0173CQ) | ELISA, FC, ADCC | Chimeric (mouse/human) IgG1, λ |
| HPAB-0174CQ | Human Anti-F3 Recombinant Antibody (HPAB-0174CQ) | ELISA, FC, ADCC | Chimeric (mouse/human) IgG1, λ |
| HPAB-0175CQ | Human Anti-F3 Recombinant Antibody (HPAB-0175CQ) | ELISA, WB, Inhib | Humanized IgG1, κ |
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